Validation of the QLQ-EN24 instrument for the assessment of health-related quality of life for women with endometrial cancer in México.

Autor: Gallardo-Rincón D; Programa de Cáncer de Ovario, Instituto Nacional de Cancerología (INCan), Mexico City, Mexico.; Departamento de Ginecología, Instituto Nacional de Cancerología (INCan), Mexico City, Mexico.; Grupo de Investigación en Cáncer de Ovario y Tumores Ginecológicos de México, A.C. (GICOM), Mexico City, Mexico., Toledo-Leyva A; Programa de Cáncer de Ovario, Instituto Nacional de Cancerología (INCan), Mexico City, Mexico.; Departamento de Ginecología, Instituto Nacional de Cancerología (INCan), Mexico City, Mexico., Bahena-González A; Programa de Cáncer de Ovario, Instituto Nacional de Cancerología (INCan), Mexico City, Mexico.; Departamento de Ginecología, Instituto Nacional de Cancerología (INCan), Mexico City, Mexico.; Grupo de Investigación en Cáncer de Ovario y Tumores Ginecológicos de México, A.C. (GICOM), Mexico City, Mexico., Montes-Servín E; Programa de Cáncer de Ovario, Instituto Nacional de Cancerología (INCan), Mexico City, Mexico.; Departamento de Ginecología, Instituto Nacional de Cancerología (INCan), Mexico City, Mexico., Pérez-Martín AR; Programa de Cáncer de Ovario, Instituto Nacional de Cancerología (INCan), Mexico City, Mexico.; Departamento de Ginecología, Instituto Nacional de Cancerología (INCan), Mexico City, Mexico., Montes-Servín E; Programa de Cáncer de Ovario, Instituto Nacional de Cancerología (INCan), Mexico City, Mexico.; Departamento de Ginecología, Instituto Nacional de Cancerología (INCan), Mexico City, Mexico., Alamilla-García GC; Programa de Cáncer de Ovario, Instituto Nacional de Cancerología (INCan), Mexico City, Mexico.; Departamento de Ginecología, Instituto Nacional de Cancerología (INCan), Mexico City, Mexico.; Grupo de Investigación en Cáncer de Ovario y Tumores Ginecológicos de México, A.C. (GICOM), Mexico City, Mexico., Carmona-Herrera DD; Subdirección de Investigación Clínica, Instituto Nacional de Cancerología, San Fernando 22, Colonia Sección XVI, Delegación Tlalpan, México City, 14080, México.; Departamento de Ginecología, Instituto Nacional de Cancerología (INCan), Mexico City, Mexico.; Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), Mexico City, Mexico., Coronel-Martínez J; Subdirección de Investigación Clínica, Instituto Nacional de Cancerología, San Fernando 22, Colonia Sección XVI, Delegación Tlalpan, México City, 14080, México.; Departamento de Ginecología, Instituto Nacional de Cancerología (INCan), Mexico City, Mexico.; Grupo de Investigación en Cáncer de Ovario y Tumores Ginecológicos de México, A.C. (GICOM), Mexico City, Mexico., Oñate-Ocaña LF; Subdirección de Investigación Clínica, Instituto Nacional de Cancerología, San Fernando 22, Colonia Sección XVI, Delegación Tlalpan, México City, 14080, México. lfonate@gmail.com.; Departamento de Ginecología, Instituto Nacional de Cancerología (INCan), Mexico City, Mexico. lfonate@gmail.com.; Grupo de Investigación en Cáncer de Ovario y Tumores Ginecológicos de México, A.C. (GICOM), Mexico City, Mexico. lfonate@gmail.com.
Jazyk: angličtina
Zdroj: Archives of gynecology and obstetrics [Arch Gynecol Obstet] 2021 Sep; Vol. 304 (3), pp. 773-782. Date of Electronic Publication: 2021 Feb 13.
DOI: 10.1007/s00404-021-05990-3
Abstrakt: Purpose: The impact of disease activity or treatments on health-related quality of life (HRQL) is crucial in Oncology, but adequate instruments for this assessment are scarce. Our aim is to validate the Mexican-Spanish version of the QLQ-EN24 questionnaire to evaluate HRQL in women with endometrial cancer (EC).
Methods: This is a prospective study of Mexican women with EC, attending a single cancer centre, who responded the QLQ-C30 and QLQ-EN24 instruments; usual psychometric analysis were performed as well as the association of HRQL scales and relevant clinical data. Correlation analysis was performed with the Spearman's method, reliability analysis with the Cronbach's alpha, known-group comparisons with the Kruskal-Wallis test, and survival analysis with the Kaplan-Meier method and Log-rank test.
Results: One hundred and eighty-nine women with EC were assessed. Most functional scales reported high values, and most symptom scales, low. Questionnaire compliance rates were high and internal consistency tests demonstrated adequate convergent and divergent validity. Cronbach's α coefficients of the five multi-item scales the QLQ-EN24 instruments were from 0.659 to 0.887. Scales of the QLQ-C30 and QLQ-EN24 instruments distinguished among clinically distinct groups of patients, particularly based on serum albumin levels. The Urological symptoms, Gastrointestinal symptoms, Body image, Pelvic pain and Taste change scales were significantly associated with OS.
Conclusion: The Mexican-Spanish version of the QLQ-EN24 questionnaire is reliable and valid for the assessment of HRQL in patients with EC and can be broadly used in multi-national clinical trials. However, conclusions derived from scales evaluating sexual function should be handled carefully.
(© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH, DE part of Springer Nature.)
Databáze: MEDLINE
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