Antibacterial and cytotoxic biflavonoids from the root bark of Ochna kirkii.
Autor: | Kalenga TM; Chemistry Department, College of Natural and Applied Sciences, University of Dar es Salaam, P.O. Box 35061, Dar es Salaam, Tanzania., Ndoile MM; Chemistry Department, College of Natural and Applied Sciences, University of Dar es Salaam, P.O. Box 35061, Dar es Salaam, Tanzania., Atilaw Y; Department of Chemistry - BMC, Uppsala University, SE-751 23 Uppsala, Sweden., Munissi JJE; Chemistry Department, College of Natural and Applied Sciences, University of Dar es Salaam, P.O. Box 35061, Dar es Salaam, Tanzania., Gilissen PJ; Institute for Molecules and Materials, Radboud University, Heyendaalseweg 135, 6525 AJ Nijmegen, the Netherlands., Rudenko A; Department of Chemistry and Molecular Biology, University of Gothenburg, SE-412 96 Gothenburg, Sweden; Centre for Antibiotic Resistance Research (CARe) at the University of Gothenburg, 40530 Gothenburg, Sweden., Bourgard C; Department of Chemistry and Molecular Biology, University of Gothenburg, SE-412 96 Gothenburg, Sweden; Centre for Antibiotic Resistance Research (CARe) at the University of Gothenburg, 40530 Gothenburg, Sweden., Sunnerhagen P; Department of Chemistry and Molecular Biology, University of Gothenburg, SE-412 96 Gothenburg, Sweden; Centre for Antibiotic Resistance Research (CARe) at the University of Gothenburg, 40530 Gothenburg, Sweden., Nyandoro SS; Chemistry Department, College of Natural and Applied Sciences, University of Dar es Salaam, P.O. Box 35061, Dar es Salaam, Tanzania. Electronic address: nyandoro@udsm.ac.tz., Erdelyi M; Department of Chemistry - BMC, Uppsala University, SE-751 23 Uppsala, Sweden. Electronic address: mate.erdelyi@kemi.uu.se. |
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Jazyk: | angličtina |
Zdroj: | Fitoterapia [Fitoterapia] 2021 Jun; Vol. 151, pp. 104857. Date of Electronic Publication: 2021 Feb 11. |
DOI: | 10.1016/j.fitote.2021.104857 |
Abstrakt: | The new isoflavonoid kirkinone A (1) and biflavonoid kirkinone B (2) along with six known compounds (3-8) were isolated from the methanolic extract of the root bark of Ochna kirkii. The compounds were identified by NMR spectroscopic and mass spectrometric analyses. Out of the eight isolated natural products, calodenin B (4) and lophirone A (6) showed significant antibacterial activity against the Gram-positive bacterium Bacillus subtilis with MIC values of 2.2 and 28 μM, and cytotoxicity against the MCF-7 human breast cancer cell line with EC (Copyright © 2021 The Authors. Published by Elsevier B.V. All rights reserved.) |
Databáze: | MEDLINE |
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