The posterior insular cortex is necessary for the consolidation of tone fear conditioning.

Autor: de Paiva JPQ; Center for Mathematics, Computing and Cognition (CMCC), Universidade Federal do ABC, São Bernardo do Campo, Brazil; Imaging Research Center, Hospital Israelita Albert Einstein, São Paulo, Brazil., Bueno APA; Center for Mathematics, Computing and Cognition (CMCC), Universidade Federal do ABC, São Bernardo do Campo, Brazil., Dos Santos Corrêa M; Center for Mathematics, Computing and Cognition (CMCC), Universidade Federal do ABC, São Bernardo do Campo, Brazil., Oliveira MGM; Department of Psychobiology, Universidade Federal de São Paulo, São Paulo, Brazil., Ferreira TL; Center for Mathematics, Computing and Cognition (CMCC), Universidade Federal do ABC, São Bernardo do Campo, Brazil., Fornari RV; Center for Mathematics, Computing and Cognition (CMCC), Universidade Federal do ABC, São Bernardo do Campo, Brazil. Electronic address: raquel.fornari@ufabc.edu.br.
Jazyk: angličtina
Zdroj: Neurobiology of learning and memory [Neurobiol Learn Mem] 2021 Mar; Vol. 179, pp. 107402. Date of Electronic Publication: 2021 Feb 11.
DOI: 10.1016/j.nlm.2021.107402
Abstrakt: The insular cortex (IC) is notably implicated in emotional and cognitive processing; however, little is known regarding to what extent its two main subregions play functionally distinct roles on memory consolidation of conditioned fear tasks. Here we verified the effects of temporary functional inactivation of the anterior (aIC) and posterior IC (pIC) on contextual and tone fear memory. Rats received post-training bilateral infusions of the GABA A receptor agonist muscimol into either the aIC or pIC and were tested 48 and 72 h after the delay tone fear conditioning session to assess the background contextual (CFC) and tone (TFC) fear conditioning, respectively. Inactivation of the aIC during memory consolidation did not affect fear memory for CFC or TFC. On the other hand, post-training inactivation of the pIC impaired TFC but not CFC. Our findings indicate that the pIC is a necessary part of the neural circuitry related to the consolidation of cued-fear memories.
(Copyright © 2021 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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