[Distracter inhibition in mild cognitive impairment].

Autor:	Velichkovsky BB; Lomonosov Moscow State University, Moscow, Russia.; Moscow Institute of Psychoanalysis, Moscow, Russia., Tatarinov DV; Lomonosov Moscow State University, Moscow, Russia., Khlebnikova AA; Lomonosov Moscow State University, Moscow, Russia., Roshchina IF; Mental Health Research Center, Moscow, Russia.; Moscow State University of Psychology and Education, Moscow, Russia., Selezneva ND; Mental Health Research Center, Moscow, Russia., Gavrilova SI; Mental Health Research Center, Moscow, Russia.
Jazyk:	ruština
Zdroj:	Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova [Zh Nevrol Psikhiatr Im S S Korsakova] 2021; Vol. 121 (1), pp. 71-76.
DOI:	10.17116/jnevro202112101171
Abstrakt:	Objective: To study the effectiveness of interfering visual stimuli inhibition using the flanker task in a group of healthy young and healthy old participants, and in a group of participants with mild cognitive impairment (MCI). Material and Methods: Reaction times and accuracy, as well as the diffusion model of reaction times with parameters reflecting perceptual and motor processes, stimulus processing speed, and conservativeness of response selection were analyzed. Results: We found reduced speed and accuracy in older age, especially in MCI patients. The reduction was especially pronounced in patients with the incongruent distracters. For diffusion model parameters, perceptual and motor processes took longer with older age, reduced processing speed was found only in pathological aging, and specific effectiveness reduction for incongruent probes in patients was driven by increased conservativeness of responses. Conclusions: The results indicate the joint influence of normal and pathological aging processes on patients with MCI. The deceleration of the perceptual-motor components of the reaction time reflects the processes of normal cognitive aging, while the deceleration of the processing speed (in the presence of any distractors, including congruent ones) characterizes pathological cognitive aging. Differential diagnosis of normal and pathological cognitive changes is possible using data based on the analysis of reaction time components. It is important to take into account the conservativeness of responses as a factor slowing down the reaction time in pathological and normal cognitive aging.
Databáze:	MEDLINE
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