Detection of 30 Fentanyl Analogs by Commercial Immunoassay Kits.

Autor:	Wharton RE; Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Hwy, Atlanta, GA 30341, USA., Casbohm J; Battelle Memorial Institute, 505 King Avenue, Columbus, OH 43201, USA., Hoffmaster R; Battelle Memorial Institute, 505 King Avenue, Columbus, OH 43201, USA., Brewer BN; Battelle Memorial Institute, 505 King Avenue, Columbus, OH 43201, USA., Finn MG; School of Chemistry and Biochemistry, School of Biological Sciences, Georgia Institute of Technology, 901 Atlantic Drive, Atlanta, GA 30332, USA., Johnson RC; Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Hwy, Atlanta, GA 30341, USA.
Jazyk:	angličtina
Zdroj:	Journal of analytical toxicology [J Anal Toxicol] 2021 Feb 13; Vol. 45 (2), pp. 111-116.
DOI:	10.1093/jat/bkaa181
Abstrakt:	Health-care workers, laboratorians and overdose prevention centers rely on commercial immunoassays to detect the presence of fentanyl; however, the cross-reactivity of fentanyl analogs with these kits is largely unknown. To address this, we conducted a pilot study evaluating the detection of 30 fentanyl analogs and metabolites by 19 commercially available kits (9 lateral flow assays, 7 heterogeneous immunoassays and 3 homogenous immunoassays). The analogs selected for analysis were compiled from the Drug Enforcement Administration and National Forensic Laboratory Information System reports from 2015 to 2018. In general, the immunoassays tested were able to detect their intended fentanyl analog and some closely related analogs, but more structurally diverse analogs, including 4-methoxy-butyryl fentanyl and 3-methylfentanyl, were not well detected. Carfentanil was only detected by kits specifically designed for its recognition. In general, analogs with group additions to the piperidine, or bulky rings or long alkyl chain modifications in the N-aryl or alkyl amide regions, were poorly detected compared to other types of modifications. This preliminary information is useful for screening diagnostic, forensic and unknown powder samples for the presence of fentanyl analogs and guiding future testing improvements. (Published by Oxford University Press on behalf of Society of Forensic Toxicologists, Inc. 2021. This work is written by (a) US Government employee(s) and is in the public domain in the US.)
Databáze:	MEDLINE
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