Gouania willdenowi is a teleost fish without immunoglobulin genes.

Autor: Mirete-Bachiller S; Unidad de Inmunología Hospital do Meixoeiro, Vigo, Spain., Olivieri DN; Centro de Intelixencia Artificial, Ourense, Spain; ESE Informatica, Universidade de Vigo, Spain. Electronic address: davidolivieri@yahoo.es., Gambón-Deza F; Unidad de Inmunología Hospital do Meixoeiro, Vigo, Spain. Electronic address: fgambon@gmail.com.
Jazyk: angličtina
Zdroj: Molecular immunology [Mol Immunol] 2021 Apr; Vol. 132, pp. 102-107. Date of Electronic Publication: 2021 Feb 10.
DOI: 10.1016/j.molimm.2021.01.022
Abstrakt: Immunoglobulin (Ig) genes encode antibodies in jawed vertebrates. They are essential elements of the adaptive immune response. Ig exists in soluble form or as part of the B cell membrane antigen receptor (BCR). Studies of Ig genes in fish genomes reveal the absence of Ig genes in Gouania willdenowi by deletion of the entire Ig locus from the canonical chromosomal region. The genes coding for integral BCR proteins, CD79a and CD79b, are also absent. Genes exist for T α/β lymphocyte receptors but not for the T γ/δ receptors. The results of the genomic analysis are independently corroborated with RNA-Seq transcriptomes from other Gobiesocidae species. From the transcriptome studies, Ig is also absent from these other Gobiesocidae species, Acyrtus sp. and Tomicodon sp. Present evidence suggests that Ig is missing from all species of the Gobiesocidae family.
(Copyright © 2021 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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