A possible role for HLA-G in development of uteroplacental acute atherosis in preeclampsia.

Autor: Johnsen GM; Institute for Clinical Medicine, Faculty of Medicine, University of Oslo, Norway; Division of Obstetrics and Gyneacology, Oslo University Hospital, Norway; Institute for Experimental Medical Research, Oslo University Hospital, Norway. Electronic address: g.m.johnsen@medisin.uio.no., Fjeldstad HES; Institute for Clinical Medicine, Faculty of Medicine, University of Oslo, Norway; Division of Obstetrics and Gyneacology, Oslo University Hospital, Norway., Drabbels JJM; Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Netherlands., Haasnoot GW; Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Netherlands., Eikmans M; Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Netherlands., Størvold GL; Institute for Clinical Medicine, Faculty of Medicine, University of Oslo, Norway; Division of Obstetrics and Gyneacology, Oslo University Hospital, Norway; Institute for Experimental Medical Research, Oslo University Hospital, Norway., Alnaes-Katjavivi P; Division of Obstetrics and Gyneacology, Oslo University Hospital, Norway., Jacobsen DP; Division of Obstetrics and Gyneacology, Oslo University Hospital, Norway., Scherjon SA; Department of Obstetrics and Gynecology, University of Groningen, Netherlands., Redman CWG; University of Oxford, UK., Claas FHJ; Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Netherlands., Staff AC; Institute for Clinical Medicine, Faculty of Medicine, University of Oslo, Norway; Division of Obstetrics and Gyneacology, Oslo University Hospital, Norway.
Jazyk: angličtina
Zdroj: Journal of reproductive immunology [J Reprod Immunol] 2021 Apr; Vol. 144, pp. 103284. Date of Electronic Publication: 2021 Feb 02.
DOI: 10.1016/j.jri.2021.103284
Abstrakt: HLA-G, a non-classical HLA molecule expressed by extravillous trophoblasts, plays a role in the maternal immune tolerance towards fetal cells. HLA-G expression is regulated by genetic polymorphisms in the 3' untranslated region (3'UTR). Low levels of HLA-G in the maternal circulation and placental tissue are linked to preeclampsia. Our objective was to investigate whether variants of the 3'UTR of the HLA-G gene in mother and fetus are associated with acute atherosis, a pregnancy specific arterial lesion of the decidua basalis that is prevalent in preeclampsia. Paired maternal and fetal DNA samples from 83 normotensive and 83 preeclamptic pregnancies were analyzed. We sequenced the part of the HLA-G 3'UTR containing a 14-bp insertion/deletion region and seven single nucleotide polymorphisms (SNPs). Associations with acute atherosis were tested by logistic regression. The frequency of heterozygosity for the 14-bp polymorphism (Ins/Del) and the +3142 SNP (C/G) variant in the fetus are associated with acute atherosis in preeclampsia (66.7 % vs. 39.6 %, p = 0.039, and 69.0 % vs. 43.4 %, p = 0.024). Furthermore, the fetal UTR-3 haplotype, which encompasses the 14-bp deletion and the +3142G variant, is associated with acute atherosis in preeclampsia (15 % vs. 3.8 %, p = 0.016). In conclusion, HLA-G polymorphisms in the fetus are associated with acute atherosis. We hypothesize that these polymorphisms lead to altered HLA-G expression in the decidua basalis, affecting local feto-maternal immune tolerance and development of acute atherosis.
(Copyright © 2021 The Authors. Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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