Antibacterial fatty acids: An update of possible mechanisms of action and implications in the development of the next-generation of antibacterial agents.

Autor: Casillas-Vargas G; Faculty of Science and Technology, Department of Natural Sciences, Inter American University of Puerto Rico, Metropolitan Campus, PO Box 191293, San Juan, PR 00919, USA., Ocasio-Malavé C; Faculty of Science and Technology, Department of Natural Sciences, Inter American University of Puerto Rico, Metropolitan Campus, PO Box 191293, San Juan, PR 00919, USA., Medina S; Faculty of Science and Technology, Department of Natural Sciences, Inter American University of Puerto Rico, Metropolitan Campus, PO Box 191293, San Juan, PR 00919, USA., Morales-Guzmán C; University of Puerto Rico, Río Piedras Campus, Department of Chemistry, 17 Ave. Universidad Ste. 1701, San Juan, PR 00925-2537, USA., Del Valle RG; University of Puerto Rico, Río Piedras Campus, Department of Chemistry, 17 Ave. Universidad Ste. 1701, San Juan, PR 00925-2537, USA., Carballeira NM; University of Puerto Rico, Río Piedras Campus, Department of Chemistry, 17 Ave. Universidad Ste. 1701, San Juan, PR 00925-2537, USA. Electronic address: nestor.carballeira1@upr.edu., Sanabria-Ríos DJ; Faculty of Science and Technology, Department of Natural Sciences, Inter American University of Puerto Rico, Metropolitan Campus, PO Box 191293, San Juan, PR 00919, USA. Electronic address: dsanabria@intermetro.edu.
Jazyk: angličtina
Zdroj: Progress in lipid research [Prog Lipid Res] 2021 Apr; Vol. 82, pp. 101093. Date of Electronic Publication: 2021 Feb 09.
DOI: 10.1016/j.plipres.2021.101093
Abstrakt: The antibacterial activity of fatty acids (FA) is well known in the literature and represents a promising option for developing the next-generation of antibacterial agents to treat a broad spectrum of bacterial infections. FA are highly involved in living organisms' defense system against numerous pathogens, including multidrug-resistant bacteria. When combined with other antibacterial agents, the remarkable ability of FA to enhance their bactericidal properties is a critical feature that is not commonly observed in other naturally-occurring compounds. More reviews focusing on FA antibacterial activity, traditional and non-traditional mechanisms and biomedical applications are needed. This review is intended to update the reader on the antibacterial properties of recent FA and how their chemical structures influence their antibacterial activity. This review also aims to better understand both traditional and non-traditional mechanisms involved in these recently explored FA antibacterial activities.
(Copyright © 2021 The Author(s). Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: