The gut microbiome modulates the protective association between a Mediterranean diet and cardiometabolic disease risk.

Autor: Wang DD; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Nguyen LH; Division of Gastroenterology, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston, MA, USA., Li Y; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Yan Y; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Ma W; Division of Gastroenterology, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston, MA, USA., Rinott E; Ben-Gurion University of the Negev, Negev, Israel., Ivey KL; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.; South Australian Health and Medical Research Institute, Infection and Immunity Theme, South Australia, Australia.; Department of Nutrition and Dietetics, College of Nursing and Health Sciences, Flinders University, Adelaide, Australia., Shai I; Ben-Gurion University of the Negev, Negev, Israel., Willett WC; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Hu FB; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Rimm EB; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Stampfer MJ; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Chan AT; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.; Division of Gastroenterology, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston, MA, USA., Huttenhower C; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA. chuttenh@hsph.harvard.edu.; Broad Institute of MIT and Harvard, Boston, MA, USA. chuttenh@hsph.harvard.edu.
Jazyk: angličtina
Zdroj: Nature medicine [Nat Med] 2021 Feb; Vol. 27 (2), pp. 333-343. Date of Electronic Publication: 2021 Feb 11.
DOI: 10.1038/s41591-020-01223-3
Abstrakt: To address how the microbiome might modify the interaction between diet and cardiometabolic health, we analyzed longitudinal microbiome data from 307 male participants in the Health Professionals Follow-Up Study, together with long-term dietary information and measurements of biomarkers of glucose homeostasis, lipid metabolism and inflammation from blood samples. Here, we demonstrate that a healthy Mediterranean-style dietary pattern is associated with specific functional and taxonomic components of the gut microbiome, and that its protective associations with cardiometabolic health vary depending on microbial composition. In particular, the protective association between adherence to the Mediterranean diet and cardiometabolic disease risk was significantly stronger among participants with decreased abundance of Prevotella copri. Our findings advance the concept of precision nutrition and have the potential to inform more effective and precise dietary approaches for the prevention of cardiometabolic disease mediated through alterations in the gut microbiome.
Databáze: MEDLINE
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