Association between the Mediterranean Diet and Metabolic Syndrome with Serum Levels of miRNA in Morbid Obesity.

Autor:	Fontalba-Romero MI; Unidad de Gestión Clínica de Endocrinología y Nutrición, Hospital Regional Universitario, 29010 Málaga, Spain., Lopez-Enriquez S; Departamento de Bioquímica Médica, Biología Molecular e Inmunología, Facultad de Medicina, Universidad de Sevilla, 41009 Sevilla, Spain.; Instituto de Investigación Biomédica de Málaga-IBIMA, 29010 Málaga, Spain., Lago-Sampedro A; Unidad de Gestión Clínica de Endocrinología y Nutrición, Hospital Regional Universitario, 29010 Málaga, Spain.; Instituto de Investigación Biomédica de Málaga-IBIMA, 29010 Málaga, Spain., García-Escobar E; Unidad de Gestión Clínica de Endocrinología y Nutrición, Hospital Regional Universitario, 29010 Málaga, Spain.; Instituto de Investigación Biomédica de Málaga-IBIMA, 29010 Málaga, Spain.; CIBER de Diabetes y Enfermedades Metabólicas (CIBERDEM), 29009 Málaga, Spain., Pastori RL; Diabetes Research Institute, University of Miami Miller School of Medicine, Miami, FL 33136, USA., Domínguez-Bendala J; Diabetes Research Institute, University of Miami Miller School of Medicine, Miami, FL 33136, USA., Álvarez-Cubela S; Diabetes Research Institute, University of Miami Miller School of Medicine, Miami, FL 33136, USA., Valdes S; Unidad de Gestión Clínica de Endocrinología y Nutrición, Hospital Regional Universitario, 29010 Málaga, Spain.; Instituto de Investigación Biomédica de Málaga-IBIMA, 29010 Málaga, Spain.; CIBER de Diabetes y Enfermedades Metabólicas (CIBERDEM), 29009 Málaga, Spain., Rojo G; Unidad de Gestión Clínica de Endocrinología y Nutrición, Hospital Regional Universitario, 29010 Málaga, Spain.; Instituto de Investigación Biomédica de Málaga-IBIMA, 29010 Málaga, Spain.; CIBER de Diabetes y Enfermedades Metabólicas (CIBERDEM), 29009 Málaga, Spain., Garcia-Fuentes E; Instituto de Investigación Biomédica de Málaga-IBIMA, 29010 Málaga, Spain.; Unidad de Gestión Clínica de Aparato Digestivo, Hospital Universitario Virgen de la Victoria, 29010 Málaga, Spain., Labajos-Manzanares MT; Faculty of Health Sciences, School of Medicine, University of Málaga, 29071 Málaga, Spain., García-Serrano S; Unidad de Gestión Clínica de Endocrinología y Nutrición, Hospital Regional Universitario, 29010 Málaga, Spain.; Instituto de Investigación Biomédica de Málaga-IBIMA, 29010 Málaga, Spain.; CIBER de Diabetes y Enfermedades Metabólicas (CIBERDEM), 29009 Málaga, Spain.
Jazyk:	angličtina
Zdroj:	Nutrients [Nutrients] 2021 Jan 29; Vol. 13 (2). Date of Electronic Publication: 2021 Jan 29.
DOI:	10.3390/nu13020436
Abstrakt:	Background: The Mediterranean diet (MD) could be involved in the regulation of different miRNAs related to metabolic syndrome (MS). Methods: We analyzed the serum level of mir-let7a-5p, mir-21, mir-590, mir-107 and mir-192 in patients with morbid obesity and its association with the MD and MS. Results: There is an association between the adherence to MD and higher serum levels of mir-590. Mir-590 was lower in those patients who consumed >2 commercial pastries/week. Mir-let7a was lower in those who consumed ≥1 sweetened drinks, in those who consumed ≥3 pieces of fruit/day and in those who consumed less red than white meat. A lower mir-590 and mir-let7a, and a higher mir-192 level, were found in patients who met the high-density lipoprotein cholesterol (HDL) criterion of MS. A higher mir-192 was found in those patients who met the triglyceride criterion of MS and in those with type 2 diabetes (T2DM). Conclusions: There is an association between specific serum levels of miRNAs and the amount and kind of food intake related to MD. Mir-590 was positively associated with a healthy metabolic profile and type of diet, while mir-192 was positively associated with a worse metabolic profile. These associations could be suggestive of a possible modulation of these miRNAs by food.
Databáze:	MEDLINE
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