Evolution and circulation of Yersinia pestis in the Northern Caspian and Northern Aral Sea regions in the 20th-21st centuries.

Autor: Eroshenko GA; Russian Research Anti-Plague Institute 'Microbe', Federal Service for Surveillance in the Sphere of Consumers Rights Protection and Human Welfare, Saratov, Russian Federation., Popov NV; Russian Research Anti-Plague Institute 'Microbe', Federal Service for Surveillance in the Sphere of Consumers Rights Protection and Human Welfare, Saratov, Russian Federation., Al'khova ZV; Russian Research Anti-Plague Institute 'Microbe', Federal Service for Surveillance in the Sphere of Consumers Rights Protection and Human Welfare, Saratov, Russian Federation., Kukleva LM; Russian Research Anti-Plague Institute 'Microbe', Federal Service for Surveillance in the Sphere of Consumers Rights Protection and Human Welfare, Saratov, Russian Federation., Balykova AN; Russian Research Anti-Plague Institute 'Microbe', Federal Service for Surveillance in the Sphere of Consumers Rights Protection and Human Welfare, Saratov, Russian Federation., Chervyakova NS; Russian Research Anti-Plague Institute 'Microbe', Federal Service for Surveillance in the Sphere of Consumers Rights Protection and Human Welfare, Saratov, Russian Federation., Naryshkina EA; Russian Research Anti-Plague Institute 'Microbe', Federal Service for Surveillance in the Sphere of Consumers Rights Protection and Human Welfare, Saratov, Russian Federation., Kutyrev VV; Russian Research Anti-Plague Institute 'Microbe', Federal Service for Surveillance in the Sphere of Consumers Rights Protection and Human Welfare, Saratov, Russian Federation.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2021 Feb 11; Vol. 16 (2), pp. e0244615. Date of Electronic Publication: 2021 Feb 11 (Print Publication: 2021).
DOI: 10.1371/journal.pone.0244615
Abstrakt: According to the whole genome SNP analysis of 38 Yersinia pestis strains isolated in the foci of the Northern Caspian and Northern Aral Sea regions in the 20th-early 21st centuries, between 1912 and 2015, the spatial and temporal structure of the 2.MED population of a medieval biovar in this region was determined. A phylogenetic branch 2.MED4 was identified which preceded the 2.MED1 branch that diverged later. 2.MED1 strains became the etiological agent of high-mortality plague outbreaks that occurred in the Northern Caspian region at the beginning of the 20th century. Later in the 20th century, the 2.MED1 branch became widespread in the Caspian Sea region, Caucasus, and vast areas of Central Asia. Based on the data of phylogenetic analysis, as well as epidemiological and epizootiological data, we reconstructed the paths of spread of the 2.MED1 branch in the Northern Caspian Sea region and in the Northern subzone of the Central Asian deserts. It is shown, that the reason for the activation of plague foci in the Northern Caspian region in the second half of the 20th century after a long inter-epizootic period caused by cyclical climate warming was the return of 2.MED1 from the foci of the Northern Aral Sea region. This led to the formation of stable plague foci in the Northern Caspian Sea region and Pre-Caucasus, which manifested epizootic activity in the second half of the 20th and early 21st centuries.
Competing Interests: The authors have declared that no competing interests exist.
Databáze: MEDLINE
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