Serotonergic modulation of basolateral amygdala nucleus in the extinction of reward-driven learning: The role of 5-HT bioavailability and 5-HT 1A receptor.

Autor: Pereyra AE; Instituto de Biologı́a y Medicina Experimental (IBYME-CONICET), Vuelta de Obligado 2490, CABA, Argentina. Electronic address: apereyra@dna.uba.ar., Mininni CJ; Instituto de Biologı́a y Medicina Experimental (IBYME-CONICET), Vuelta de Obligado 2490, CABA, Argentina; Universidad de Buenos Aires, Facultad de Ingenierı́a, Instituto de Ingenierı́a Biomédica (IIBM), CABA, Argentina. Electronic address: cmininni@fi.uba.ar., Zanutto BS; Instituto de Biologı́a y Medicina Experimental (IBYME-CONICET), Vuelta de Obligado 2490, CABA, Argentina; Universidad de Buenos Aires, Facultad de Ingenierı́a, Instituto de Ingenierı́a Biomédica (IIBM), CABA, Argentina. Electronic address: silvano@fi.uba.ar.
Jazyk: angličtina
Zdroj: Behavioural brain research [Behav Brain Res] 2021 Apr 23; Vol. 404, pp. 113161. Date of Electronic Publication: 2021 Feb 08.
DOI: 10.1016/j.bbr.2021.113161
Abstrakt: Serotonin (5-HT) neurotransmission has been associated with reward-related behaviour. Moreover, the serotonergic system modulates the basolateral amygdala (BLA), a structure involved in reward encoding, and reward prediction error. However, the role played by 5-HT on BLA during a reward-driven task has not been fully elucidated. In this paper, we investigated whether serotonergic modulation of the BLA is involved in reward-driven learning. To this end, we trained Long Evans rats in an operant conditioning task, and examined the effects of fluoxetine treatment (a selective serotonin reuptake inhibitor, 10 mg/kg) in combination with BLA lesions with NMDA (20 mg/mL) on extinction learning. We also investigated whether intra-BLA injection of the serotonergic 5-HT 1A receptor agonist 8-OH DPAT, or antagonist WAY-100635, alters extinction performance. We found that fluoxetine treatment strongly accelerated extinction learning, while BLA lesions partially reverted this effect and slightly impaired consolidation of extinction. Stimulation and inhibition of 5-HT 1A receptors in BLA induced opposite effects to those of fluoxetine, impairing or accelerating extinction performance, respectively. Our findings suggest that 5-HT modulates reward-driven learning, and 5-HT 1A receptors located in the BLA are relevant for extinction.
(Copyright © 2021 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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