Role of cholecystokinin and oxytocin in slower gastric emptying induced by physical exercise in rats.

Autor: Tolentino Bento da Silva M; Department of Physical Education, Federal University of Piaui, Teresina, PI, Brazil. Electronic address: tolentino@ufpi.edu.br., Palheta-Junior RC; School of Veterinary Medicine, Federal University of Vale do São Francisco, Petrolina, PE, Brazil., Silva CMS; Department of Physiology and Pharmacology, School of Medicine, Federal University of Ceará, Fortaleza, CE, Brazil., Cavalcante AKM; Department of Physiology and Pharmacology, School of Medicine, Federal University of Ceará, Fortaleza, CE, Brazil., Quetz JDS; Department of Physiology and Pharmacology, School of Medicine, Federal University of Ceará, Fortaleza, CE, Brazil., Havt A; Department of Physiology and Pharmacology, School of Medicine, Federal University of Ceará, Fortaleza, CE, Brazil., de Lima JBM; Wayne State University, Department of Biological Sciences, Detroit, MI, USA., Mecawi AS; Department of Biophisics, Palista School of Medicine, Federal University of São Paulo, São Paulo, SP, Brazil., de Castro M; School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil., Antunes-Rodrigues J; School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil., de Oliveira RB; School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil., Magalhães PJC; Department of Physiology and Pharmacology, School of Medicine, Federal University of Ceará, Fortaleza, CE, Brazil., Aguiar Dos Santos A; Department of Physiology and Pharmacology, School of Medicine, Federal University of Ceará, Fortaleza, CE, Brazil.
Jazyk: angličtina
Zdroj: Physiology & behavior [Physiol Behav] 2021 May 01; Vol. 233, pp. 113355. Date of Electronic Publication: 2021 Feb 09.
DOI: 10.1016/j.physbeh.2021.113355
Abstrakt: Vigorous exercise can induce gastrointestinal disorders such decreased gastric emptying pace, while low-intensity exercise can accelerate gastric motility. However, the mechanisms of these effects are still unknown. We investigated the possible neurohumoral mechanisms involved in these phenomena. In sedentary (Sed) and acute exercise (Ex) groups of rats, we assessed the activation of c-Fos in NTS and DVMN and the plasma levels of CCK and OXT. Separate groups received pretreatment with the oxytocin antagonist atosiban (AT), the cholecystokinin antagonist devazepide (DVZ), or the TRPV 1 receptor inhibitor capsazepine (CAPZ). AT, DVZ and CAPZ treatments prevented (p<0.05) slower gastric emptying induced by acute exercise. The gene expression of OXT decreased (P<0.05) while that of CCK increased (P<0.05) in the gastric fundus and pylorus of the Ex group, while the plasma levels of OXT rose (p<0.05) and of CCK declined (p<5.05). We also observed activation (p<0.05) of c-Fos-sensitive neurons in the NTS and DVMN of exercised rats. In conclusion, acute exercise slowed gastric emptying by the vagal afferent pathway, which involved activation of CCK 1 /OXT/TRPV 1 sensitivity.
(Copyright © 2021 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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