Faecal immunochemical tests for haemoglobin: Analytical challenges and potential solutions.

Autor: Benton SC; Clinical Biochemistry, Royal Surrey County Hospital/NHS Bowel Cancer Screening South of England Hub, Berkshire and Surrey Pathology Services, Guildford, Surrey, UK., Symonds E; Bowel Health Service, Flinders Medical Centre, Bedford Park, South Australia, Australia; Cancer Research, Flinders Health and Medical Research, Flinders University, Bedford Park, South Australia, Australia., Djedovic N; Clinical Biochemistry/NHS Bowel Cancer Screening London Hub, London North West University Healthcare NHS Trust, UK., Jones S; Weqas, Cardiff and Vale University Health Board, Cardiff, Wales, UK., Deprez L; European Commission, Joint Research Centre (JRC), Geel, Belgium., Kocna P; Laboratory of Gastroenterology, Institute of Medical Biochemistry and Laboratory Diagnostics, 1st.Medical Faculty of Charles University and General University Hospital, Prague, Czech Republic., Maria Auge J; Clinical Chemistry and Molecular Genetics Department, Hospital Clinic, Barcelona, Catalonia, Spain.
Jazyk: angličtina
Zdroj: Clinica chimica acta; international journal of clinical chemistry [Clin Chim Acta] 2021 Jun; Vol. 517, pp. 60-65. Date of Electronic Publication: 2021 Feb 09.
DOI: 10.1016/j.cca.2021.01.024
Abstrakt: Quantitative faecal immunochemical tests for haemoglobin (FIT) are being used increasingly around the world in colorectal cancer screening programmes, and in patients presenting with lower bowel symptoms to determine who should proceed to further bowel visualisation investigations, usually colonoscopy. The clinical utility of FIT is well reported. There are a number of analytical challenges including pre-analytical variation, difficulty setting up external quality assessment schemes, access to third party internal quality control material and a lack of standardisation or harmonisation of FIT methods. Here we report the work of the International Federation of Clinical Chemistry FIT Working Group. We provide an overview of the main pre-analytical variables; discuss different approaches to external quality assurance of FIT; propose a solution to third party internal quality assurance materials and summarise the challenges of standardisation and harmonisation of FIT.
(Copyright © 2021. Published by Elsevier B.V.)
Databáze: MEDLINE
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