Integrated network analysis reveals new genes suggesting COVID-19 chronic effects and treatment.

Autor: Pavel A; Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; BioMediTech Institute, Tampere University, Tampere, Finland., Del Giudice G; Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; BioMediTech Institute, Tampere University, Tampere, Finland., Federico A; Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; BioMediTech Institute, Tampere University, Tampere, Finland., Di Lieto A; Department of Forensic Psychiatry, Aarhus University, Aarhus, Denmark., Kinaret PAS; Institute of Biotechnology, University of Helsinki, Helsinki, Finland., Serra A; Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; BioMediTech Institute, Tampere University, Tampere, Finland., Greco D; Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; BioMediTech Institute, Tampere University, Tampere, Finland.; Institute of Biotechnology, University of Helsinki, Helsinki, Finland.
Jazyk: angličtina
Zdroj: Briefings in bioinformatics [Brief Bioinform] 2021 Mar 22; Vol. 22 (2), pp. 1430-1441.
DOI: 10.1093/bib/bbaa417
Abstrakt: The COVID-19 disease led to an unprecedented health emergency, still ongoing worldwide. Given the lack of a vaccine or a clear therapeutic strategy to counteract the infection as well as its secondary effects, there is currently a pressing need to generate new insights into the SARS-CoV-2 induced host response. Biomedical data can help to investigate new aspects of the COVID-19 pathogenesis, but source heterogeneity represents a major drawback and limitation. In this work, we applied data integration methods to develop a Unified Knowledge Space (UKS) and used it to identify a new set of genes associated with SARS-CoV-2 host response, both in vitro and in vivo. Functional analysis of these genes reveals possible long-term systemic effects of the infection, such as vascular remodelling and fibrosis. Finally, we identified a set of potentially relevant drugs targeting proteins involved in multiple steps of the host response to the virus.
(© The Author(s) 2021. Published by Oxford University Press.)
Databáze: MEDLINE
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