A Novel Computerized Cognitive Stress Test to Detect Mild Cognitive Impairment.

Autor: Curiel Cid RE; Rosie E. Curiel, Psy.D., Associate Professor of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, 1695 NW 9th Avenue, Suite 3202, Miami, FL 33136. RCuriel2@miami.edu., Crocco EA, Kitaigorodsky M, Beaufils L, Peña PA, Grau G, Visser U, Loewenstein DA
Jazyk: angličtina
Zdroj: The journal of prevention of Alzheimer's disease [J Prev Alzheimers Dis] 2021; Vol. 8 (2), pp. 135-141.
DOI: 10.14283/jpad.2021.1
Abstrakt: Background: The Loewenstein Acevedo Scales of Semantic Interference and Learning (LASSI-L) is a novel and increasingly employed instrument that has outperformed widely used cognitive measures as an early correlate of elevated brain amyloid and neurodegeneration in prodromal Alzheimer's Disease (AD). The LASSI-L has distinguished those with amnestic mild cognitive impairment (aMCI) and high amyloid load from aMCI attributable to other non-AD conditions. The authors designed and implemented a web-based brief computerized version of the instrument, the LASSI-BC, to improve standardized administration, facilitate scoring accuracy, real-time data entry, and increase the accessibility of the measure.
Objective: The psychometric properties and clinical utility of the brief computerized version of the LASSI-L was evaluated, together with its ability to differentiate older adults who are cognitively normal (CN) from those with amnestic Mild Cognitive Impairment (aMCI).
Methods: After undergoing a comprehensive uniform clinical and neuropsychological evaluation using traditional measures, older adults were classified as cognitively normal or diagnosed with aMCI. All participants were administered the LASSI-BC, a computerized version of the LASSI-L. Test-retest and discriminant validity was assessed for each LASSI-BC subscale.
Results: LASSI-BC subscales demonstrated high test-retest reliability, and discriminant validity was attained.
Conclusions: The LASSI-BC, a brief computerized version of the LASSI-L is a valid and useful cognitive tool for the detection of aMCI among older adults.
Competing Interests: Drs. Curiel and Loewenstein have intellectual property used in this study.
Databáze: MEDLINE
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