Eccentric Left Ventricular Hypertrophy and Left and Right Cardiac Function in Chronic Heart Failure with or without Coexisting COPD: Impact on Exercise Performance.

Autor: Dos Santos PB; Cardiopulmonary Physical Therapy Laboratory, Federal University of Sao Carlos, Sao Carlos, Brazil., Simões RP; Cardiopulmonary Physical Therapy Laboratory, Federal University of Sao Carlos, Sao Carlos, Brazil.; Postgraduate Program in Rehabilitation Sciences, Federal University of Alfenas, Minas Gerais, Brazil., Goulart CDL; Cardiopulmonary Physical Therapy Laboratory, Federal University of Sao Carlos, Sao Carlos, Brazil., Roscani MG; Department of Medicine, Federal University of Sao Carlos, Sao Carlos, Brazil., Marinho RS; Cardiopulmonary Physical Therapy Laboratory, Federal University of Sao Carlos, Sao Carlos, Brazil., Camargo PF; Cardiopulmonary Physical Therapy Laboratory, Federal University of Sao Carlos, Sao Carlos, Brazil., Arbex RF; Cardiopulmonary Physical Therapy Laboratory, Federal University of Sao Carlos, Sao Carlos, Brazil., Casale G; Department of Medicine, Federal University of Sao Carlos, Sao Carlos, Brazil., Oliveira CR; Department of Medicine, Federal University of Sao Carlos, Sao Carlos, Brazil., Mendes RG; Cardiopulmonary Physical Therapy Laboratory, Federal University of Sao Carlos, Sao Carlos, Brazil., Arena R; Department of Physical Therapy, College of Applied Health Sciences, University of Illinois at Chicago, Chicago, IL, USA., Borghi-Silva A; Cardiopulmonary Physical Therapy Laboratory, Federal University of Sao Carlos, Sao Carlos, Brazil.
Jazyk: angličtina
Zdroj: International journal of chronic obstructive pulmonary disease [Int J Chron Obstruct Pulmon Dis] 2021 Feb 03; Vol. 16, pp. 203-214. Date of Electronic Publication: 2021 Feb 03 (Print Publication: 2021).
DOI: 10.2147/COPD.S285812
Abstrakt: Aim: Our aim was to assess: 1) the impact of the eccentric left ventricular hypertrophy (ELVH) on exercise performance in patients diagnosed with chronic heart failure (CHF) alone and in patients with co-existing CHF and chronic obstructive pulmonary disease (COPD) and 2) the relationship between left and right cardiac function measurements obtained by doppler echocardiography, clinical characteristics and primary measures of cardiorespiratory fitness.
Methods: The current study included 46 patients (CHF:23 and CHF+COPD:23) that performed advanced pulmonary function tests, echocardiography and symptom-limited, incremental cardiopulmonary exercise testing (CPET) on a cycle ergometer.
Results: Patients with CHF+COPD demonstrated a lower work rate, peak oxygen uptake (VO 2 ), oxygen pulse, rate pressure product (RPP), circulatory power (CP) and ventilatory power (VP) compared to those only diagnosed with CHF. In addition, significant correlations were observed between VP and relative wall thickness (r: 0.45 p: 0.03),V E /VCO 2 intercept and Mitral E/e' ratio (r: 0.70 p: 0.003) in the CHF group. Significant correlations were found between indexed left ventricle mass and RPP (r: -0.47; p: 0.02) and relative VO 2 and right ventricle diameter (r: -0.62; p: 0.001) in the CHF+COPD group.
Conclusion: Compared to a diagnosis of CHF alone, a combined diagnosis of CHF+COPD induced further impairments in cardiorespiratory fitness. Moreover, echocardiographic measures of cardiac function are related to cardiopulmonary exercise performance and therefore appear to be an important therapeutic target when attempting to improve exercise performance and functional capacity.
Competing Interests: Polliana Dos Santos reports grants from Fundação de Amparo a Pesquisa do Estado de São Paulo, outside the submitted work. The authors report no other potential conflicts of interest for this work and no relationships that could be construed as a conflict of interest.
(© 2021 Dos Santos et al.)
Databáze: MEDLINE
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