Potential Interplay between Nrf2, TRPA1, and TRPV1 in Nutrients for the Control of COVID-19.

Autor:	Bousquet J; Department of Dermatology and Allergy, Comprehensive Allergy Center, Charité, and Berlin Institute of Health, Comprehensive Allergy Center, Universitätsmedizin Berlin, Humboldt-Universität zu Berlin, Berlin, Germany, jean.bousquet@orange.fr.; University Hospital and MACVIA France, Montpellier, France, jean.bousquet@orange.fr., Czarlewski W; Medical Consulting Czarlewski, Levallois, France.; MASK-air, Montpellier, France., Zuberbier T; Department of Dermatology and Allergy, Comprehensive Allergy Center, Charité, and Berlin Institute of Health, Comprehensive Allergy Center, Universitätsmedizin Berlin, Humboldt-Universität zu Berlin, Berlin, Germany., Mullol J; Rhinology Unit & Smell Clinic, ENT Department, Hospital Clinic - Clinical & Experimental Respiratory Immunoallergy, IDIBAPS, CIBERES, Universitat de Barcelona, Barcelona, Spain., Blain H; Department of Geriatrics, Montpellier University Hospital, Montpellier, France., Cristol JP; Laboratoire de Biochimie et Hormonologie, PhyMedExp, Université de Montpellier, INSERM, CNRS, CHU de, Montpellier, France., De La Torre R; CIBER Fisiopatologia de la Obesidad y Nutrición (CIBEROBN), Madrid, Spain.; IMIM (Hospital del Mar Research Institute), Barcelona, Spain.; Departament de Ciències Experimentals i de la Salut Toxicologia, Universitat Pompeu Fabra (UPF), Barcelona, Spain., Pizarro Lozano N; IMIM (Hospital del Mar Research Institute), Barcelona, Spain., Le Moing V; Maladies Infectieuses et Tropicales, CHU, Montpellier, France., Bedbrook A; University Hospital and MACVIA France, Montpellier, France.; MASK-air, Montpellier, France., Agache I; Faculty of Medicine, Transylvania University, Brasov, Romania., Akdis CA; Christine Kühne - Center for Allergy Research and Education (CK-CARE), Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Zurich, Switzerland., Canonica GW; Personalized Medicine, Asthma and Allergy, Humanitas Clinical and Research Center IRCCS and Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy., Cruz AA; Fundação ProAR, Federal University of Bahia and GARD/WHO Planning Group, Salvador, Brazil., Fiocchi A; Division of Allergy, The Bambino Gesù Children's Research Hospital IRCCS, Rome, Italy., Fonseca JA; CINTESIS, Center for Research in Health Technologies and Information Systems, Faculdade de Medicina da Universidade do Porto, Porto, Portugal.; MEDIDA, Lda, Porto, Portugal., Fonseca S; GreenUPorto - Sustainable Agrifood Production Research Centre, DGAOT, Faculty of Sciences, University of Porto, Vila do Conde, Portugal., Gemicioğlu B; Department of Pulmonary Diseases, Istanbul University-Cerrahpasa, Cerrahpasa Faculty of Medicine, Istanbul, Turkey., Haahtela T; Skin and Allergy Hospital, Helsinki University Hospital, and University of Helsinki, Helsinki, Finland., Iaccarino G; Interdepartmental Center of Research on Hypertension and Related Conditions CIRIAPA, Federico II University, Napoli, Italy., Ivancevich JC; Servicio de Alergia e Immunologia, Clinica Santa Isabel, Buenos Aires, Argentina., Jutel M; Department of Clinical Immunology, Wrocław Medical University and ALL-MED Medical Research Institute, Wrocław, Poland., Klimek L; Center for Rhinology and Allergology, Wiesbaden, Germany., Kraxner H; Department of Otorhinolaryngology, Head and Neck Surgery, Semmelweis University, Budapest, Hungary., Kuna P; Division of Internal Medicine, Asthma and Allergy, Barlicki University Hospital, Medical University of Lodz, Lodz, Poland., Larenas-Linnemann DE; Center of Excellence in Asthma and Allergy, Médica Sur Clinical Foundation and Hospital, Mexico City, Mexico., Martineau A; Institute for Population Health Sciences, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom., Melén E; Institute of Environmental Medicine, Karolinska Institutet and Sachs' Children's Hospital, Stockholm, Sweden., Okamoto Y; Department of Otorhinolaryngology, Chiba University Hospital, Chiba, Japan., Papadopoulos NG; Division of Infection, Immunity & Respiratory Medicine, Royal Manchester Children's Hospital, University of Manchester, Manchester, United Kingdom.; Allergy Department, 2nd Pediatric Clinic, Athens General Children's Hospital 'P&A Kyriakou,' University of Athens, Athens, Greece., Pfaar O; Section of Rhinology and Allergy, Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Marburg, Philipps-Universität Marburg, Marburg, Germany., Regateiro FS; Allergy and Clinical Immunology Unit, Centro Hospitalar e Universitário de Coimbra, Faculty of Medicine, Institute of Immunology, University of Coimbra, Coimbra, Portugal.; Faculty of Medicine, ICBR - Institute for Clinical and Biomedical Research, CIBB, University of Coimbra, Coimbra, Portugal., Reynes J; Maladies Infectieuses et Tropicales, CHU, Montpellier, France., Rolland Y; CHU Toulouse, Toulouse, France., Rouadi PW; Department of Otolaryngology-Head and Neck Surgery, Eye and Ear University Hospital, Beirut, Lebanon., Samolinski B; Department of Prevention of Environmental Hazards and Allergology, Medical University of Warsaw, Warsaw, Poland., Sheikh A; Usher Institute, The University of Edinburgh, Edinburgh, United Kingdom., Toppila-Salmi S; Skin and Allergy Hospital, Helsinki University Hospital, and University of Helsinki, Helsinki, Finland., Valiulis A; Vilnius University Faculty of Medicine, Institute of Clinical Medicine & Institute of Health Sciences, Vilnius, Lithuania., Choi HJ; Research and Development Division, Microbiology and Functionality Research Group, World Institute of Kimchi, Gwangju, Republic of Korea., Kim HJ; Strategy and Planning Division, SME Service Department, World Institute of Kimchi, Gwangju, Republic of Korea., Anto JM; IMIM (Hospital del Mar Research Institute), Barcelona, Spain.; Departament de Ciències Experimentals i de la Salut Toxicologia, Universitat Pompeu Fabra (UPF), Barcelona, Spain.; CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain.; ISGlobAL, Barcelona, Centre for Research in Environmental Epidemiology, Barcelona, Spain.
Jazyk:	angličtina
Zdroj:	International archives of allergy and immunology [Int Arch Allergy Immunol] 2021; Vol. 182 (4), pp. 324-338. Date of Electronic Publication: 2021 Feb 10.
DOI:	10.1159/000514204
Abstrakt:	In this article, we propose that differences in COVID-19 morbidity may be associated with transient receptor potential ankyrin 1 (TRPA1) and/or transient receptor potential vanilloid 1 (TRPV1) activation as well as desensitization. TRPA1 and TRPV1 induce inflammation and play a key role in the physiology of almost all organs. They may augment sensory or vagal nerve discharges to evoke pain and several symptoms of COVID-19, including cough, nasal obstruction, vomiting, diarrhea, and, at least partly, sudden and severe loss of smell and taste. TRPA1 can be activated by reactive oxygen species and may therefore be up-regulated in COVID-19. TRPA1 and TRPV1 channels can be activated by pungent compounds including many nuclear factor (erythroid-derived 2) (Nrf2)-interacting foods leading to channel desensitization. Interactions between Nrf2-associated nutrients and TRPA1/TRPV1 may be partly responsible for the severity of some of the COVID-19 symptoms. The regulation by Nrf2 of TRPA1/TRPV1 is still unclear, but suggested from very limited clinical evidence. In COVID-19, it is proposed that rapid desensitization of TRAP1/TRPV1 by some ingredients in foods could reduce symptom severity and provide new therapeutic strategies. (© 2021 S. Karger AG, Basel.)
Databáze:	MEDLINE
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