| Autor: |
Antunes-Foschini R; Department of Ophthalmology, Otorhinolaryngology and Head and Neck Surgery, Faculdade de Medicina de Ribeirão, Universidade de São Paulo, Ribeirão Preto, SP, Brazil., Adriano L; Department of Ophthalmology, Otorhinolaryngology and Head and Neck Surgery, Faculdade de Medicina de Ribeirão, Universidade de São Paulo, Ribeirão Preto, SP, Brazil., Murashima AAB; Department of Ophthalmology, Otorhinolaryngology and Head and Neck Surgery, Faculdade de Medicina de Ribeirão, Universidade de São Paulo, Ribeirão Preto, SP, Brazil., Barbosa AP; Department of Ophthalmology, Otorhinolaryngology and Head and Neck Surgery, Faculdade de Medicina de Ribeirão, Universidade de São Paulo, Ribeirão Preto, SP, Brazil., Nominato LF; Department of Ophthalmology, Otorhinolaryngology and Head and Neck Surgery, Faculdade de Medicina de Ribeirão, Universidade de São Paulo, Ribeirão Preto, SP, Brazil., Dias LC; Department of Ophthalmology, Otorhinolaryngology and Head and Neck Surgery, Faculdade de Medicina de Ribeirão, Universidade de São Paulo, Ribeirão Preto, SP, Brazil., Fantucci MZ; Department of Ophthalmology, Otorhinolaryngology and Head and Neck Surgery, Faculdade de Medicina de Ribeirão, Universidade de São Paulo, Ribeirão Preto, SP, Brazil., Garcia DM; Department of Ophthalmology, Otorhinolaryngology and Head and Neck Surgery, Faculdade de Medicina de Ribeirão, Universidade de São Paulo, Ribeirão Preto, SP, Brazil., Alves M; Discipline of Ophthalmology and Otorhinolaryngology, Faculdade de Ciências Médicas, Universidade Estadual de Campinas, Campinas, SP, Brazil., Rocha EM; Department of Ophthalmology, Otorhinolaryngology and Head and Neck Surgery, Faculdade de Medicina de Ribeirão, Universidade de São Paulo, Ribeirão Preto, SP, Brazil. |
| Abstrakt: |
This review is intended to describe the therapeutic approaches for corneal blindness, detailing the steps and elements involved in corneal wound healing. It also presents the limitations of the actual surgical and pharmacological strategies used to restore and maintain corneal transparency in terms of long-term survival and geographic coverage. In addition, we critically review the perspectives of anabolic agents, including vitamin A, hormones, growth factors, and novel promitotic and anti-inflammatory modulators, to assist corneal wound healing. We discuss the studies involving nanotechnology, gene therapy, and tissue reengineering as potential future strategies to work solely or in combination with corneal surgery to prevent or revert corneal blindness. |
