Epidemiology of dengue fever in Gabon: Results from a health facility-based fever surveillance in Lambaréné and its surroundings.

Autor: Lim JK; International Vaccine Institute, Seoul, Republic of Korea., Fernandes JF; Centre de Recherches Médicales de Lambaréné, Campus CERMEL, Lambaréné, Gabon.; Department of Medicine I, Division of Infectious Diseases and Tropical Medicine, Medical University of Vienna, Vienna, Austria.; Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany., Yoon IK; Coalition for Epidemic Preparedness Innovations (CEPI), Washington, DC, USA., Lee JS; International Vaccine Institute, Seoul, Republic of Korea., Mba RO; Centre de Recherches Médicales de Lambaréné, Campus CERMEL, Lambaréné, Gabon., Lee KS; International Vaccine Institute, Seoul, Republic of Korea., Namkung S; International Vaccine Institute, Seoul, Republic of Korea., Yang JS; International Vaccine Institute, Seoul, Republic of Korea., Bae SH; International Vaccine Institute, Seoul, Republic of Korea., Lim SK; International Vaccine Institute, Seoul, Republic of Korea., Lell B; Centre de Recherches Médicales de Lambaréné, Campus CERMEL, Lambaréné, Gabon.; Department of Medicine I, Division of Infectious Diseases and Tropical Medicine, Medical University of Vienna, Vienna, Austria., Esen M; Centre de Recherches Médicales de Lambaréné, Campus CERMEL, Lambaréné, Gabon.; Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany.; German Centre for Infection Research (DZIF), Partner Site Tübingen, Germany and CERMEL, Lambaréné, Gabon., Loembe MM; Centre de Recherches Médicales de Lambaréné, Campus CERMEL, Lambaréné, Gabon.; Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany., Kremsner PG; Centre de Recherches Médicales de Lambaréné, Campus CERMEL, Lambaréné, Gabon.; Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany., Alexander N; MRC International Statistics and Epidemiology Group, London School of Hygiene and Tropical Medicine, London, United Kingdom., Agnandji ST; Centre de Recherches Médicales de Lambaréné, Campus CERMEL, Lambaréné, Gabon.; Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany.; German Centre for Infection Research (DZIF), Partner Site Tübingen, Germany and CERMEL, Lambaréné, Gabon.
Jazyk: angličtina
Zdroj: PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2021 Feb 10; Vol. 15 (2), pp. e0008861. Date of Electronic Publication: 2021 Feb 10 (Print Publication: 2021).
DOI: 10.1371/journal.pntd.0008861
Abstrakt: Background: In Africa, information on dengue is limited to outbreak reports and focused on some countries with continuing transmission in West and East Africa. To estimate the proportion of dengue-positive cases among febrile patients and identify clinical indicators of dengue cases, we conducted passive facility-based fever surveillance in a catchment area population of 70,000 residents of Lambaréné and its surroundings in Gabon.
Methods: Non-malarial febrile patients with current fever or history of fever (≤7 days) between 1 and 55 years of age, were enrolled at Albert Schweitzer Hospital (ASH). Acute (visit 1, day of enrollment) and convalescent blood samples were collected between 10 and 21 days after enrollment. Acute/convalescent samples were tested with IgM/IgG ELISA, and a selected subset of acute samples with RT-PCR.
Results: Among 682 non-malarial febrile patients enrolled, 119 (17.4%) were identified as dengue-positive (94 dengue-confirmed and 25 dengue-probable cases). Of these dengue-positive cases, 14 were confirmed with PCR, and based on serotyping, two infections were identified to be DENV-2 and two were DENV-3. The majority of our enrolled patients were <25 years of age and close to 80% of our dengue-positive cases were <15 years of age. In adjusted analyses, retro-orbital pain and abdominal pain were 2.7 and 1.6 times more frequently found among dengue-positive cases, compared to non-dengue cases.
Conclusion: Lambaréné is not considered dengue-endemic. However, one in six non-malarial febrile episodes was found to be dengue-positive in the study period. Dengue should be considered more frequently in clinicians' diagnosis among non-malarial febrile patients in Lambaréné. Given the lack of data on dengue in Gabon, additional prospective and longitudinal studies would help to further define the burden and patterns of dengue for improved case detection.
Competing Interests: The authors have declared that no competing interests exist.
Databáze: MEDLINE
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