Emergence of an early SARS-CoV-2 epidemic in the United States.

Autor: Zeller M; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA., Gangavarapu K; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA., Anderson C; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA., Smither AR; Department of Microbiology and Immunology, School of Medicine, Tulane University, New Orleans, LA 70112, USA., Vanchiere JA; Department of Pediatrics, Louisiana State University Health Sciences Center - Shreveport, Shreveport, LA 71130, USA., Rose R; BioInfoExperts LLC, Thibodaux, Louisiana, USA., Snyder DJ; Department of Microbiology and Molecular Genetics, University of Pittsburgh, School of Medicine, Pittsburgh, PA, 15219, USA.; Center for Evolutionary Biology and Medicine, University of Pittsburgh, Pittsburgh, PA, 15219, USA., Dudas G; Gothenburg Global Biodiversity Centre (GGBC), Gothenburg, Sweden., Watts A; Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Canada.; Bluedot, Toronto, Canada., Matteson NL; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA., Robles-Sikisaka R; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA., Marshall M; Department of Civil and Systems Engineering, Johns Hopkins University, Baltimore, MD, USA., Feehan AK; Ochsner Clinic Foundation, New Orleans, Louisiana, USA., Sabino-Santos G Jr; Department of Tropical Medicine, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA 70112, USA.; Centre for Virology Research, Ribeirão Preto Medical School, University of Sao Paulo, Ribeirao Preto, SP 14049900, Brazil., Bell-Kareem AR; Department of Microbiology and Immunology, School of Medicine, Tulane University, New Orleans, LA 70112, USA., Hughes LD; Department of Integrative, Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA., Alkuzweny M; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA., Snarski P; Heart and Vascular Institute, John W. Deming Department of Medicine, School of Medicine, Tulane University, New Orleans, LA 70112, USA.; Department of Physiology, Tulane University School of Medicine, New Orleans, LA 70112, USA; Department of Pediatrics, School of Medicine, University of California San Diego, La Jolla, California, USA., Garcia-Diaz J; Ochsner Clinic Foundation, New Orleans, Louisiana, USA., Scott RS; Department of Microbiology and Immunology, Louisiana State University Health Science Center Shreveport, Shreveport, LA 71103, USA; Center for Microbiome Innovation, Jacobs School of Engineering, University of California San Diego, La Jolla, California, USA., Melnik LI; Department of Microbiology and Immunology, School of Medicine, Tulane University, New Orleans, LA 70112, USA., Klitting R; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA., McGraw M; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA., Belda-Ferre P; Department of Physiology, Tulane University School of Medicine, New Orleans, LA 70112, USA; Department of Pediatrics, School of Medicine, University of California San Diego, La Jolla, California, USA.; Department of Microbiology and Immunology, Louisiana State University Health Science Center Shreveport, Shreveport, LA 71103, USA; Center for Microbiome Innovation, Jacobs School of Engineering, University of California San Diego, La Jolla, California, USA., DeHoff P; Department of Obstetrics, Gynecology, and Reproductive Science, University of California, San Diego, La Jolla, CA 92037, USA., Sathe S; Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, California 92093, USA.; Stem Cell Program, University of California San Diego, La Jolla, CA 92093, USA., Marotz C; Department of Physiology, Tulane University School of Medicine, New Orleans, LA 70112, USA; Department of Pediatrics, School of Medicine, University of California San Diego, La Jolla, California, USA.; Scripps Institution of Oceanography, University of California San Diego, La Jolla, California, USA., Grubaugh N; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, 06510, USA., Nolan DJ; BioInfoExperts LLC, Thibodaux, Louisiana, USA., Drouin AC; Department of Microbiology and Immunology, School of Medicine, Tulane University, New Orleans, LA 70112, USA.; Department of Physiology, Tulane University School of Medicine, New Orleans, LA 70112, USA; Department of Pediatrics, School of Medicine, University of California San Diego, La Jolla, California, USA., Genemaras KJ; Department of Microbiology and Immunology, School of Medicine, Tulane University, New Orleans, LA 70112, USA.; Bioinnovation Program, Tulane University, New Orleans, LA 70118, USA., Chao K; Department of Microbiology and Immunology, School of Medicine, Tulane University, New Orleans, LA 70112, USA.; Bioinnovation Program, Tulane University, New Orleans, LA 70118, USA., Topol S; Scripps Research Translational Institute, La Jolla, CA 92037, USA., Spencer E; Scripps Research Translational Institute, La Jolla, CA 92037, USA., Nicholson L; Scripps Research Translational Institute, La Jolla, CA 92037, USA., Aigner S; Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, California 92093, USA.; Stem Cell Program, University of California San Diego, La Jolla, CA 92093, USA.; Institute for Genomic Medicine, University of California, San Diego, La Jolla, California, USA., Yeo GW; Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, California 92093, USA.; Stem Cell Program, University of California San Diego, La Jolla, CA 92093, USA.; Institute for Genomic Medicine, University of California, San Diego, La Jolla, California, USA., Farnaes L; Rady Children's Institute for Genomic Medicine, San Diego, CA 92123, USA; Rady Children's Hospital, San Diego, CA 92123, USA., Hobbs CA; Rady Children's Institute for Genomic Medicine, San Diego, CA 92123, USA; Rady Children's Hospital, San Diego, CA 92123, USA., Laurent LC; Department of Obstetrics, Gynecology, and Reproductive Science, University of California, San Diego, La Jolla, CA 92037, USA., Knight R; Department of Physiology, Tulane University School of Medicine, New Orleans, LA 70112, USA; Department of Pediatrics, School of Medicine, University of California San Diego, La Jolla, California, USA.; Department of Microbiology and Immunology, Louisiana State University Health Science Center Shreveport, Shreveport, LA 71103, USA; Center for Microbiome Innovation, Jacobs School of Engineering, University of California San Diego, La Jolla, California, USA.; Department of Computer Science and Engineering, Jacobs School of Engineering, University of California San Diego, La Jolla, California, USA.; Department of Bioengineering, University of California San Diego, La Jolla, California, USA., Hodcroft EB; Biozentrum, University of Basel, Basel, Switzerland., Khan K; Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Canada.; Bluedot, Toronto, Canada.; Department of Medicine, University of Toronto, Toronto, Canada., Fusco DN; Department of Tropical Medicine, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA 70112, USA.; Department of Medicine, Tulane University School of Medicine, 1430 Tulane Avenue, New Orleans, LA, 70114, USA., Cooper VS; Department of Microbiology and Molecular Genetics, University of Pittsburgh, School of Medicine, Pittsburgh, PA, 15219, USA.; Center for Evolutionary Biology and Medicine, University of Pittsburgh, Pittsburgh, PA, 15219, USA., Lemey P; Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, Belgium.; Global Virology Network., Gardner L; Department of Civil and Systems Engineering, Johns Hopkins University, Baltimore, MD, USA., Lamers SL; BioInfoExperts LLC, Thibodaux, Louisiana, USA., Kamil JP; Department of Microbiology and Immunology, Louisiana State University Health Science Center Shreveport, Shreveport, LA 71103, USA; Center for Microbiome Innovation, Jacobs School of Engineering, University of California San Diego, La Jolla, California, USA., Garry RF; Department of Microbiology and Immunology, School of Medicine, Tulane University, New Orleans, LA 70112, USA.; Zalgen Labs LLC, Germantown, MD, USA., Suchard MA; Department of Biostatistics, Fielding School of Public Health, University of California, Los Angeles, Los Angeles, CA 90095, USA.; Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA., Andersen KG; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.; Scripps Institution of Oceanography, University of California San Diego, La Jolla, California, USA.
Jazyk: angličtina
Zdroj: MedRxiv : the preprint server for health sciences [medRxiv] 2021 Feb 08. Date of Electronic Publication: 2021 Feb 08.
DOI: 10.1101/2021.02.05.21251235
Abstrakt: The emergence of the early COVID-19 epidemic in the United States (U.S.) went largely undetected, due to a lack of adequate testing and mitigation efforts. The city of New Orleans, Louisiana experienced one of the earliest and fastest accelerating outbreaks, coinciding with the annual Mardi Gras festival, which went ahead without precautions. To gain insight into the emergence of SARS-CoV-2 in the U.S. and how large, crowded events may have accelerated early transmission, we sequenced SARS-CoV-2 genomes during the first wave of the COVID-19 epidemic in Louisiana. We show that SARS-CoV-2 in Louisiana initially had limited sequence diversity compared to other U.S. states, and that one successful introduction of SARS-CoV-2 led to almost all of the early SARS-CoV-2 transmission in Louisiana. By analyzing mobility and genomic data, we show that SARS-CoV-2 was already present in New Orleans before Mardi Gras and that the festival dramatically accelerated transmission, eventually leading to secondary localized COVID-19 epidemics throughout the Southern U.S.. Our study provides an understanding of how superspreading during large-scale events played a key role during the early outbreak in the U.S. and can greatly accelerate COVID-19 epidemics on a local and regional scale.
Databáze: MEDLINE