Podocyte and tubular involvement in AngioJet-induced kidney injury.

Autor: Esteras R; Department of Nephrology, Fundacion Jimenez Diaz Health Research Institute (IIS-FJD), Autonoma University of Madrid, Madrid, Spain.; Red de Investigacion Renal, Madrid, Spain., Cannata-Ortiz P; Red de Investigacion Renal, Madrid, Spain.; Department of Pathology, Fundacion Jimenez Diaz University Hospital, Madrid, Spain., Del Palacio-Tamarit M; Department of Internal Medicine, Fundacion Jimenez Diaz University Hospital, Madrid, Spain., Guerrero-Hue M; Renal, Vascular and Diabetes Research Laboratory, Fundacion Jimenez Diaz Health Research Institute, Autonoma University of Madrid, Madrid, Spain.; Department of Cell Biology, Physiology and Immunology, Maimonides Biomedical Research Institute of Cordoba, University of Córdoba, Córdoba, Spain., García-Caballero C; Renal, Vascular and Diabetes Research Laboratory, Fundacion Jimenez Diaz Health Research Institute, Autonoma University of Madrid, Madrid, Spain.; Department of Cell Biology, Physiology and Immunology, Maimonides Biomedical Research Institute of Cordoba, University of Córdoba, Córdoba, Spain., Egido J; Department of Nephrology, Fundacion Jimenez Diaz Health Research Institute (IIS-FJD), Autonoma University of Madrid, Madrid, Spain.; Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders, Madrid, Spain., Gimeno J; Department of Pathology, Hospital del Mar, Barcelona, Spain., Ortiz A; Department of Nephrology, Fundacion Jimenez Diaz Health Research Institute (IIS-FJD), Autonoma University of Madrid, Madrid, Spain.; Red de Investigacion Renal, Madrid, Spain., Gracia-Iguacel C; Department of Nephrology, Fundacion Jimenez Diaz Health Research Institute (IIS-FJD), Autonoma University of Madrid, Madrid, Spain.; Red de Investigacion Renal, Madrid, Spain., Moreno JA; Renal, Vascular and Diabetes Research Laboratory, Fundacion Jimenez Diaz Health Research Institute, Autonoma University of Madrid, Madrid, Spain.; Department of Cell Biology, Physiology and Immunology, Maimonides Biomedical Research Institute of Cordoba, University of Córdoba, Córdoba, Spain.
Jazyk: angličtina
Zdroj: Clinical kidney journal [Clin Kidney J] 2019 Aug 23; Vol. 14 (1), pp. 424-428. Date of Electronic Publication: 2019 Aug 23 (Print Publication: 2021).
DOI: 10.1093/ckj/sfz104
Abstrakt: The AngioJet technique combines localized thrombolysis and percutaneous mechanical thrombectomy (PMT). However, PMT may cause acute kidney injury (AKI), which has been ascribed to severe mechanical haemolysis, although no renal biopsies have been reported. We now report the first renal biopsy in a patient with AKI following PMT. There is histological evidence of haemoglobin (Hb)-induced tubular injury and podocyte stress characterized by intracellular Hb and staining for ferritin and hemo-oxygenase-1, suggestive of an adaptive response to oxidative stress. This confirms that Hb is involved in kidney cell injury and supports the existence of several different kidney cellular targets.
(© The Author(s) 2019. Published by Oxford University Press on behalf of ERA-EDTA.)
Databáze: MEDLINE
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