Prevalence and Determinants of Medication Adherence among Patients with HIV/AIDS in Southern Vietnam.

Autor: Nguyen PM; Department of Pediatrics, Can Tho University of Medicine and Pharmacy, Can Tho 900000, Vietnam., Thach AN; Soc Trang Center for Disease Control, Soc Trang 96000, Vietnam., Pham XD; Department of Biomedical Sciences and Engineering, National Central University, Taoyuan 320317, Taiwan., Lam AN; Department of Epidemiology, Can Tho University of Medicine and Pharmacy, Can Tho 900000, Vietnam., Nguyen TNP; Department of Pharmacology and Clinical Pharmacy, Can Tho University of Medicine and Pharmacy, Can Tho 900000, Vietnam., Duong CX; Department of Pharmacology and Clinical Pharmacy, Can Tho University of Medicine and Pharmacy, Can Tho 900000, Vietnam., Nguyen LV; Department of Anatomy, Can Tho University of Medicine and Pharmacy, Can Tho 900000, Vietnam., Nguyen TH; Department of Clinical Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh 710000, Vietnam., Pham ST; Department of Pharmacology and Clinical Pharmacy, Can Tho University of Medicine and Pharmacy, Can Tho 900000, Vietnam., Taxis K; Groningen Research Institute of Pharmacy, University of Groningen, 9713 AV Groningen, The Netherlands., Nguyen T; Department of Pharmacology and Clinical Pharmacy, Can Tho University of Medicine and Pharmacy, Can Tho 900000, Vietnam.
Jazyk: angličtina
Zdroj: Infectious disease reports [Infect Dis Rep] 2021 Feb 05; Vol. 13 (1), pp. 126-135. Date of Electronic Publication: 2021 Feb 05.
DOI: 10.3390/idr13010014
Abstrakt: This study was conducted to determine the prevalence and determinants of medication adherence among patients with HIV/AIDS in southern Vietnam.
Methods: A cross-sectional study was conducted in a hospital in southern Vietnam from June to December 2019 on patients who began antiretroviral therapy (ART) for at least 6 months. Using a designed questionnaire, patients were considered adherent if they took correct medicines with right doses, on time and properly with food and beverage and had follow-up visits as scheduled. Multivariable logistic regression was used to identify determinants of adherence.
Key Findings: A total of 350 patients (from 861 medical records) were eligible for the study. The majority of patients were male (62.9%), and the dominant age group (≥35 years old) accounted for 53.7% of patients. Sexual intercourse was the primary route of transmission of HIV (95.1%). The proportions of participants who took the correct medicine and at a proper dose were 98.3% and 86.3%, respectively. In total, 94.9% of participants took medicine appropriately in combination with food and beverage, and 75.7% of participants were strictly adherent to ART. The factors marital status (odds ratio (OR) = 2.54; 95%CI = 1.51-4.28), being away from home (OR = 1.7; 95%CI = 1.03-2.78), substance abuse (OR = 2.7; 95%CI = 1.44-5.05), general knowledge about ART (OR = 2.75; 95%CI = 1.67-4.53), stopping medication after improvement (OR = 4.16; 95%CI = 2.29-7.56) and self-assessment of therapy adherence (OR = 9.83; 95%CI = 5.44-17.77) were significantly associated with patients' adherence.
Conclusions: Three-quarters of patients were adherent to ART. Researchers should consider these determinants of adherence in developing interventions in further studies.
Databáze: MEDLINE
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