Cognitive function in association with high estradiol levels resulting from fertility treatment.
Autor: | Leeners B; Department of Reproductive Endocrinology, University hospital Zürich, 8910 Zurich, Frauenklinikstr. 10, Switzerland. Electronic address: Brigitte.Leeners@usz.ch., Krüger T; Department of Psychiatry, Social Psychiatry and Psychotherapy, Medical School Hannover, Hannover, Germany. Electronic address: Krueger.Tillmann@mh-hannover.de., Geraedts K; Department of Reproductive Endocrinology, University hospital Zürich, 8910 Zurich, Frauenklinikstr. 10, Switzerland. Electronic address: Kirsten.Geraedts@usz.ch., Tronci E; Department of Computer Science, University of Roma 'La Sapienza', Roma, Italy. Electronic address: tronci@di.uniroma1.it., Mancini T; Department of Computer Science, University of Roma 'La Sapienza', Roma, Italy. Electronic address: tmancini@di.uniroma1.it., Ille F; Center of Competence in Aerospace Biomedical Science & Technology, Lucerne University of Applied Sciences and Arts, Hergiswil, Switzerland. Electronic address: fabian.ille@hslu.ch., Egli M; Center of Competence in Aerospace Biomedical Science & Technology, Lucerne University of Applied Sciences and Arts, Hergiswil, Switzerland. Electronic address: marcel.egli@hslu.ch., Röblitz S; Computational Biology Unit, Department of Informatics, University of Bergen, Bergen, Norway. Electronic address: susanna.roblitz@uib.no., Wunder D; Center for Reproductive Medicine and Gynecological Endocrinology, Lausanne, Switzerland. Electronic address: dorothea.wunder@cpma.ch., Saleh L; Institute of Clinical Chemistry, University hospital Zürich, Zürich, Switzerland. Electronic address: Lanja.Saleh@usz.ch., Schippert C; Department of Gynecology and Obstetrics, Hannover Medical School, Hannover, Germany. Electronic address: schippert.cordula@mh-hannover.de., Hengartner MP; Department of Applied Psychology, Zurich University for Applied Sciences (ZHAW), Zürich, Switzerland. Electronic address: heng@zhaw.ch. |
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Jazyk: | angličtina |
Zdroj: | Hormones and behavior [Horm Behav] 2021 Apr; Vol. 130, pp. 104951. Date of Electronic Publication: 2021 Feb 11. |
DOI: | 10.1016/j.yhbeh.2021.104951 |
Abstrakt: | The putative association between hormones and cognitive performance is controversial. While there is evidence that estradiol plays a neuroprotective role, hormone treatment has not been shown to improve cognitive performance. Current research is flawed by the evaluation of combined hormonal effects throughout the menstrual cycle or in the menopausal transition. The stimulation phase of a fertility treatment offers a unique model to study the effect of estradiol on cognitive function. This quasi-experimental observational study is based on data from 44 women receiving IVF in Zurich, Switzerland. We assessed visuospatial working memory, attention, cognitive bias, and hormone levels at the beginning and at the end of the stimulation phase of ovarian superstimulation as part of a fertility treatment. In addition to inter-individual differences, we examined intra-individual change over time (within-subject effects). The substantial increases in estradiol levels resulting from fertility treatment did not relate to any considerable change in cognitive functioning. As the tests applied represent a broad variety of cognitive functions on different levels of complexity and with various brain regions involved, we can conclude that estradiol does not show a significant short-term effect on cognitive function. (Copyright © 2021. Published by Elsevier Inc.) |
Databáze: | MEDLINE |
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