[Surgical management of brain metastases following female reproductive system cancers: analysis of 37 cases].

Autor:	Sevyan NV; Blokhin National Cancer Medical Research Center, Moscow, Russia.; Sechenov First Moscow State Medical University, Moscow, Russia., Karakhan VB; Blokhin National Cancer Medical Research Center, Moscow, Russia., Prozorenko EV; Sechenov First Moscow State Medical University, Moscow, Russia., Bekyashev AK; Blokhin National Cancer Medical Research Center, Moscow, Russia., Mitrofanov AA; Blokhin National Cancer Medical Research Center, Moscow, Russia.
Jazyk:	ruština
Zdroj:	Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko [Zh Vopr Neirokhir Im N N Burdenko] 2021; Vol. 85 (1), pp. 56-67.
DOI:	10.17116/neiro20218501156
Abstrakt:	Background. Previously, treatment of women with brain metastases following reproductive system cancers was palliative and included whole brain radiotherapy. Currently, treatment approaches have changed and life expectancy has increased. Nevertheless, the role of surgical treatment in these patients is still discussed. Objective: To demonstrate an appropriateness and role of neurosurgical care in the complex management of women with brain metastases following reproductive system cancers. Material and Methods: There were 78 women with brain metastases following reproductive system cancer. All patients were treated at the Blokhin National Cancer Medical Research Center for the period 2004-2019. We have also reviewed the literature data for the last 30 years. Results and discussion. Resection of brain metastases in complex treatment of endometrial, ovarian and cervical cancer ensured favorable long-term survival in our material. Thus, mean life expectancy after resection of brain metastases was 16.3 months in patients with ovarian cancer, uterine cancer - 15.6 months, cervical cancer - 10.25 months. Obviously, surgery is not indicated in all cases. However, this approach improves local control and should be used in combination with other treatment methods for improvement of life expectancy and its quality in certain patients. Conclusion: Selective surgical approach should be essential in the treatment of patients with brain metastases following reproductive system cancer. A multidisciplinary approach ensures the best treatment outcomes.
Databáze:	MEDLINE
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