| Autor: |
da Silva MA; Department of Medicine, Genetics, Indiana University School of Medicine, Indianapolis 46223., Heerema N, Schwenk GR Jr, Hoffman R |
| Jazyk: |
angličtina |
| Zdroj: |
Cancer genetics and cytogenetics [Cancer Genet Cytogenet] 1988 May; Vol. 32 (1), pp. 109-15. |
| DOI: |
10.1016/0165-4608(88)90317-2 |
| Abstrakt: |
Hypereosinophilic syndrome (HES) is a disease process of unknown pathogenesis. Although some cases are believed to be primary hematologic malignancies, this issue remains unsolved. We present a case of HES in whom we have observed a clone of cytogenetically abnormal cells in the bone marrow in parallel with a clinical picture of a hematologic disorder characterized by progressive proliferation and organ infiltration by eosinophils. The cytogenetic abnormality 46,XY,t(7;12)(q11;p11) is previously unreported. Our case, plus other evidence present in the literature, supports the concept that HES is a hematologic malignant neoplasia. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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