Efficacy of transforaminal epidural magnesium administration when combined with a local anaesthetic and steroid in the management of lower limb radicular pain.

Autor: Awad M; Anesthesia and Pain Management, Faculty of Medicine, Al-Fayoum Univeresity, Al-Fayoum, Egypt., Raouf MM; Faculty of medicine, ElMinia university, ElMinia, Egypt., Mikhail HK; Faculty of medicine, ElMinia university, ElMinia, Egypt., Megalla SA; Faculty of medicine, ElMinia university, ElMinia, Egypt., Hamawy TY; Faculty of Medicine, Ain Shams University, Cairo, Egypt., Mohamed AH; Faculty of medicine, ElMinia university, ElMinia, Egypt.
Jazyk: angličtina
Zdroj: European journal of pain (London, England) [Eur J Pain] 2021 Jul; Vol. 25 (6), pp. 1274-1282. Date of Electronic Publication: 2021 Mar 16.
DOI: 10.1002/ejp.1748
Abstrakt: Background: Lower limb radicular pain resulting from a herniated intervertebral disc is a cause of functional disability and could lead to increased consumption of opioids. We evaluated the efficacy of epidural magnesium combined with a local anaesthetic and steroid in the management of this pain.
Methods: This was a prospective, case-control, randomized, double-blind study. Fifty patients each received 2 ml bupivacaine, 1 ml (40 mg) methylprednisolone and 1 ml saline (0.9%) (group C) or magnesium (200 mg) instead of saline (group M). The primary outcome measure was the improvement in the pain score (assessed using a visual analogue scale (VAS)), and the secondary outcome was the improvement in the functional ability (assessed using the Modified Oswestry Disability Questionnaire (MODQ)). The VAS and MODQ scores were assessed before and at 1 day, 1 week, 1 month and 3 months post-intervention.
Results: The VAS and MODQ scores were significantly better in group M compared to those in group C at all times post-injection (p-value < 0.001). Comparisons within the same group showed that the VAS and MODQ scores were significantly better at all post-injection time points compared to the pre-injection scores in both group C and group M (p-values < 0.0001).
Conclusions: Adding magnesium to a local anaesthetic and steroid to be injected in the transforaminal epidural space could improve the pain and the quality of life in patients suffering from lower limb radicular pain due to lumbo-sacral disc herniation, and this improvement could last for up to 3 months.
Significance: Magnesium is efficient when added to local anaesthetics and steroids for management of lower limb radicular pain.
(© 2021 European Pain Federation - EFIC®.)
Databáze: MEDLINE
Externí odkaz: