The Novel Ultrasonographic Marker of Uterocervical Angle for Prediction of Spontaneous Preterm Birth in Singleton and Twin Pregnancies: A Systematic Review and Meta-Analysis.

Autor:	Hessami K; Maternal-Fetal Medicine Research Center, Shiraz University of Medical Sciences, Shiraz, Iran, hessamikamran@gmail.com.; Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran, hessamikamran@gmail.com., Kasraeian M; Maternal-Fetal Medicine Research Center, Shiraz University of Medical Sciences, Shiraz, Iran., Sepúlveda-Martínez Á; Maternal and Fetal Medicine Unit, Department of Obstetrics and Gynecology Hospital Clínico de la Universidad de Chile, Santiago de Chile, Chile., Parra-Cordero MC; Maternal and Fetal Medicine Unit, Department of Obstetrics and Gynecology Hospital Clínico de la Universidad de Chile, Santiago de Chile, Chile., Vafaei H; Maternal-Fetal Medicine Research Center, Shiraz University of Medical Sciences, Shiraz, Iran., Asadi N; Maternal-Fetal Medicine Research Center, Shiraz University of Medical Sciences, Shiraz, Iran., Benito Vielba M; Department of Obstetrics and Gynecology, Miguel Servet University Hospital, Zaragoza, Spain.
Jazyk:	angličtina
Zdroj:	Fetal diagnosis and therapy [Fetal Diagn Ther] 2021 Feb 08, pp. 1-7. Date of Electronic Publication: 2021 Feb 08.
DOI:	10.1159/000510648
Abstrakt:	The alteration of the uterocervical angle (UCA) has been proposed to play an important role in spontaneous preterm birth (sPTB). The aim of this systematic review and meta-analysis was to evaluate the evidence on the UCA predictive role in sPTB. In this study, PubMed, Web of Science, Scopus, and Google scholar were systematically searched from inception up to June 2020. Inter-study heterogeneity was also assessed using Cochrane's Q test and the I2 statistic. Afterward, the random-effects model was used to pool the weighted mean differences (WMDs) and the corresponding 95% confidence intervals (CIs). Eleven articles that reported second-trimester UCA of 5,061 pregnancies were included in this study. Our meta-analysis results indicate that a wider UCA significantly increases the risk of sPTB in following cases: all pregnancies (WMD = 15.25, 95% CI: 11.78-18.72, p < 0.001; I2 = 75.9%, p < 0.001), singleton (WMD = 14.43, 95% CI: 8.79-20.06, p < 0.001; I2 = 82.4%, p < 0.001), and twin pregnancies (WMD = 15.14, 95% CI: 13.42-16.87, p < 0.001; I2 = 0.0%, p = 0.464). A wider ultrasound-measured UCA in the second trimester seems to be associated with the increased risk of sPTB in both singleton and twin pregnancies, which reinforces the clinical evidence that UCA has the potential to be used as a predictive marker of sPTB. (© 2021 S. Karger AG, Basel.)
Databáze:	MEDLINE
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