Health Care Workers' Reasons for Choosing Between Two Different COVID-19 Prophylaxis Trials in an Acute Pandemic Context: Single-Center Questionnaire Study.

Autor: Borobia AM; Clinical Pharmacology Department, La Paz University Hospital (IdiPAZ), School of Medicine, Universidad Autónoma de Madrid, Madrid, Spain., García-García I; Clinical Pharmacology Department, La Paz University Hospital (IdiPAZ), School of Medicine, Universidad Autónoma de Madrid, Madrid, Spain., Díaz-García L; Clinical Pharmacology Department, La Paz University Hospital (IdiPAZ), School of Medicine, Universidad Autónoma de Madrid, Madrid, Spain., Rodríguez-Mariblanca A; Clinical Pharmacology Department, La Paz University Hospital (IdiPAZ), School of Medicine, Universidad Autónoma de Madrid, Madrid, Spain., Martínez de Soto L; Clinical Pharmacology Department, La Paz University Hospital (IdiPAZ), School of Medicine, Universidad Autónoma de Madrid, Madrid, Spain., Monserrat Villatoro J; Clinical Pharmacology Department, La Paz University Hospital (IdiPAZ), School of Medicine, Universidad Autónoma de Madrid, Madrid, Spain., Seco Meseguer E; Clinical Pharmacology Department, La Paz University Hospital (IdiPAZ), School of Medicine, Universidad Autónoma de Madrid, Madrid, Spain., González JJ; Internal Medicine Department, La Paz University Hospital (IdiPAZ), School of Medicine, Universidad Autónoma de Madrid, Madrid, Spain., Frías Iniesta J; Clinical Pharmacology Department, La Paz University Hospital (IdiPAZ), School of Medicine, Universidad Autónoma de Madrid, Madrid, Spain., Ramírez García E; Clinical Pharmacology Department, La Paz University Hospital (IdiPAZ), School of Medicine, Universidad Autónoma de Madrid, Madrid, Spain., Arribas JR; Internal Medicine Department, La Paz University Hospital (IdiPAZ), School of Medicine, Universidad Autónoma de Madrid, Madrid, Spain., Carcas-Sansuán AJ; Clinical Pharmacology Department, La Paz University Hospital (IdiPAZ), School of Medicine, Universidad Autónoma de Madrid, Madrid, Spain.
Jazyk: angličtina
Zdroj: Journal of medical Internet research [J Med Internet Res] 2021 Feb 25; Vol. 23 (2), pp. e23441. Date of Electronic Publication: 2021 Feb 25.
DOI: 10.2196/23441
Abstrakt: Background: In April 2020, two independent clinical trials to assess SARS-CoV-2 prophylaxis strategies among health care workers were initiated at our hospital: MeCOVID (melatonin vs placebo) and EPICOS (tenofovir disoproxil/emtricitabine vs hydroxychloroquine vs combination therapy vs placebo).
Objective: This study aimed to evaluate the reasons why health care workers chose to participate in the MeCOVID and EPICOS trials, as well as why they chose one over the other.
Methods: Both trials were offered to health care workers through an internal news bulletin. After an initial screening visit, all subjects were asked to respond to a web-based survey.
Results: In the first month, 206 health care workers were screened and 160 were randomized. The survey participation was high at 73.3%. Health care workers cited "to contribute to scientific knowledge" (n=80, 53.0%), followed by "to avoid SARS-CoV-2 infection" (n=33, 21.9%) and "the interest to be tested for SARS-CoV-2" (n=28, 18.5%), as their primary reasons to participate in the trials. We observed significant differences in the expected personal benefits across physicians and nurses (P=.01). The vast majority of volunteers (n=202, 98.0%) selected the MeCOVID trial, their primary reason being their concern regarding adverse reactions to treatments in the EPICOS trial (n=102, 69.4%).
Conclusions: Health care workers' reasons to participate in prophylaxis trials in an acute pandemic context appear to be driven largely by their desire to contribute to science and to gain health benefits. Safety outweighed efficacy when choosing between the two clinical trials.
(©Alberto M Borobia, Irene García-García, Lucía Díaz-García, Amelia Rodríguez-Mariblanca, Lucía Martínez de Soto, Jaime Monserrat Villatoro, Enrique Seco Meseguer, Juan J González, Jesús Frías Iniesta, Elena Ramírez García, Jose Ramón Arribas, Antonio J Carcas-Sansuán. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 25.02.2021.)
Databáze: MEDLINE
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