Lifetime alcohol intake, drinking patterns over time and risk of stomach cancer: A pooled analysis of data from two prospective cohort studies.

Autor: Jayasekara H; Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia.; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.; Centre for Alcohol Policy Research, La Trobe University, Bundoora, Victoria, Australia., MacInnis RJ; Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia.; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia., Lujan-Barroso L; Unit of Nutrition and Cancer, Catalan Institute of Oncology - ICO, Nutrition and Cancer Group, Bellvitge Biomedical Research Institute - IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain.; Department of Nursing of Public Health, Mental Health and Maternity and Child Health School of Nursing Universitat de Barcelona, Barcelona, Spain., Mayen-Chacon AL; Nutritional Methodology and Biostatistics Group, International Agency for Research on Cancer, World Health Organization, Lyon, France., Cross AJ; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK., Wallner B; Department of Surgical and Perioperatve Sciences, Surgery, Umeå University Hospital, Umeå, Sweden., Palli D; Cancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network - ISPRO, Florence, Italy., Ricceri F; Department of Clinical and Biological Sciences, University of Turin, Turin, Italy.; Unit of Epidemiology, Regional Health Service ASL TO3, Grugliasco, Italy., Pala V; Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy., Panico S; Dipartimento di Medicina Clinica e Chirurgia, Federico II University, Naples, Italy., Tumino R; Cancer Registry and Histopathology Department, Provincial Health Authority (ASP), Ragusa, Italy., Kühn T; Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany., Kaaks R; Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany., Tsilidis K; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK., Sánchez MJ; Escuela Andaluza de Salud Pública (EASP), Granada, Spain.; Instituto de Investigación Biosanitaria ibs.GRANADA, Granada, Spain.; CIBER in Epidemiology and Public Health (CIBERESP), Madrid, Spain.; Universidad de Granada, Granada, Spain., Amiano P; CIBER in Epidemiology and Public Health (CIBERESP), Madrid, Spain.; Public Health Division of Gipuzkoa, BioDonostia Research Institute, Donostia-San Sebastian, Spain., Ardanaz E; CIBER in Epidemiology and Public Health (CIBERESP), Madrid, Spain.; Navarra Public Health Institute, Pamplona, Spain.; IdiSNA, Navarra Institute for Health Research, Pamplona, Spain., Chirlaque López MD; CIBER in Epidemiology and Public Health (CIBERESP), Madrid, Spain.; Department of Epidemiology, Regional Health Council, IMIB-Arrixaca, Murcia University, Murcia, Spain., Merino S; Public Health Directorate, Regional Government of Asturias, Oviedo, Spain., Rothwell JA; CESP (U1018), Faculté de médecine, Université Paris-Saclay, UVSQ, INSERM, Villejuif, France.; Gustave Roussy, Villejuif, France., Boutron-Ruault MC; CESP (U1018), Faculté de médecine, Université Paris-Saclay, UVSQ, INSERM, Villejuif, France.; Gustave Roussy, Villejuif, France., Severi G; CESP (U1018), Faculté de médecine, Université Paris-Saclay, UVSQ, INSERM, Villejuif, France.; Gustave Roussy, Villejuif, France.; Department of Statistics, Computer Science and Applications 'G. Parenti' (DISIA), University of Florence, Florence, Italy., Sternby H; Department of Surgery, Institution of Clinical Sciences Malmö, Lund University, Lund, Sweden., Sonestedt E; Nutritional Epidemiology, Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden., Bueno-de-Mesquita B; Department for Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands., Boeing H; Institute of Nutrition Science, University of Potsdam, Nuthetal, Germany., Travis R; Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK., Sandanger TM; Department of Community Medicine, Faculty of Health Sciences, UiT-the Arctic University of Norway, Tromsø, Norway., Trichopoulou A; Hellenic Health Foundation, Athens, Greece., Karakatsani A; Hellenic Health Foundation, Athens, Greece.; 2nd Pulmonary Medicine Department, School of Medicine, National Kapodistrian University of Athens, 'ATTIKON' University Hospital, Haidari, Greece., Peppa E; Hellenic Health Foundation, Athens, Greece., Tjønneland A; Danish Cancer Society Research Center, Copenhagen, Denmark.; Department of Public Health, University of Copenhagen, Copenhagen, Denmark., Yang Y; Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia.; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia., Hodge AM; Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia.; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia., Mitchell H; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Kensington, New South Wales, Australia., Haydon A; Department of Medical Oncology, Alfred Hospital, Melbourne, Victoria, Australia., Room R; Centre for Alcohol Policy Research, La Trobe University, Bundoora, Victoria, Australia.; Centre for Social Research on Alcohol and Drugs, Department of Public Health Sciences, Stockholm University, Stockholm, Sweden., Hopper JL; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia., Weiderpass E; Office of the Director, International Agency for Research on Cancer, World Health Organization, Lyon, France., Gunter MJ; Nutritional Epidemiology Group, International Agency for Research on Cancer, World Health Organization, Lyon, France., Riboli E; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK., Giles GG; Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia.; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia., Milne RL; Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia.; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia., Agudo A; Unit of Nutrition and Cancer, Catalan Institute of Oncology - ICO, Nutrition and Cancer Group, Bellvitge Biomedical Research Institute - IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain., English DR; Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia.; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia., Ferrari P; Nutritional Methodology and Biostatistics Group, International Agency for Research on Cancer, World Health Organization, Lyon, France.
Jazyk: angličtina
Zdroj: International journal of cancer [Int J Cancer] 2021 Jun 01; Vol. 148 (11), pp. 2759-2773. Date of Electronic Publication: 2021 Feb 22.
DOI: 10.1002/ijc.33504
Abstrakt: Alcohol consumption is causally linked to several cancers but the evidence for stomach cancer is inconclusive. In our study, the association between long-term alcohol intake and risk of stomach cancer and its subtypes was evaluated. We performed a pooled analysis of data collected at baseline from 491 714 participants in the European Prospective Investigation into Cancer and Nutrition and the Melbourne Collaborative Cohort Study. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated for incident stomach cancer in relation to lifetime alcohol intake and group-based life course intake trajectories, adjusted for potential confounders including Helicobacter pylori infection. In all, 1225 incident stomach cancers (78% noncardia) were diagnosed over 7 094 637 person-years; 984 in 382 957 study participants with lifetime alcohol intake data (5 455 507 person-years). Although lifetime alcohol intake was not associated with overall stomach cancer risk, we observed a weak positive association with noncardia cancer (HR = 1.03, 95% CI: 1.00-1.06 per 10 g/d increment), with a HR of 1.50 (95% CI: 1.08-2.09) for ≥60 g/d compared to 0.1 to 4.9 g/d. A weak inverse association with cardia cancer (HR = 0.93, 95% CI: 0.87-1.00) was also observed. HRs of 1.48 (95% CI: 1.10-1.99) for noncardia and 0.51 (95% CI: 0.26-1.03) for cardia cancer were observed for a life course trajectory characterized by heavy decreasing intake compared to light stable intake (P homogeneity = .02). These associations did not differ appreciably by smoking or H pylori infection status. Limiting alcohol use during lifetime, particularly avoiding heavy use during early adulthood, might help prevent noncardia stomach cancer. Heterogeneous associations observed for cardia and noncardia cancers may indicate etiologic differences.
(© 2021 The Authors. International Journal of Cancer published by John Wiley & Sons Ltd on behalf of UICC.)
Databáze: MEDLINE
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