Chemoradiation induced multiple sclerosis-like demyelination.

Autor:	Borges A; Radiology Department, Instituto Português de Oncologia Francisco Gentil, Centro de Lisboa, Rua Prof. Lima Basto, 1099-023 Lisbon, Portugal.; Radiology Department, Champalimaud Foundation for the unknown, Av. Brasília, 1400-038 Lisbon, Portugal., Garcez D; Neurology Department, Instituto Português de Oncologia Francisco Gentil, Centro de Lisboa, Lisbon, Portugal., Pedro C; Radiotherapy Department, Instituto Português de Oncologia Francisco Gentil, Centro de Lisboa, Lisbon, Portugal., Passos J; Neurology Department, Instituto Português de Oncologia Francisco Gentil, Centro de Lisboa, Lisbon, Portugal.
Jazyk:	angličtina
Zdroj:	ENeurologicalSci [eNeurologicalSci] 2021 Jan 20; Vol. 22, pp. 100315. Date of Electronic Publication: 2021 Jan 20 (Print Publication: 2021).
DOI:	10.1016/j.ensci.2021.100315
Abstrakt:	We report the case of a 28-year-old man, diagnosed with a non-secreting, non-metastatic suprasellar germinoma treated with chemoradiation who developed, four months after completion of radiation therapy, multiple discrete demyelinating lesions mimicking multiple sclerosis (MS). The patient had no previous diagnosis of MS and the neuroimaging studies performed both at the time of diagnosis and after chemotherapy, pre-irradiation, showed no evidence of white matter lesions. He remained asymptomatic, with no focal neurological deficits. Biochemical analysis of the CSF was positive for the intrathecal synthesis of IgG with oligoclonal bands. Follow-up MRI six months later showed a spontaneous decrease in lesion size and resolution of associated inflammatory signs, with lesions remaining stable in number. We discuss the potential origin of these white matter lesions, which may correspond to MS-like late-delayed demyelination secondary to chemoradiation therapy, in a previously predisposed patient. Competing Interests: None. (© 2021 The Authors.)
Databáze:	MEDLINE
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