Retrospective meta-transcriptomic identification of severe dengue in a traveller returning from Africa to Sweden, 1990.

Autor:	Alfsnes K; Infectious Disease Control and Environmental Health, Norwegian Institute of Public Health, Oslo, Norway., Lagerqvist N; Public Health Agency of Sweden, Nobels väg 18, SE-171 82 Solna, Sweden., Vene S; Public Health Agency of Sweden, Nobels väg 18, SE-171 82 Solna, Sweden., Bohlin J; Infectious Disease Control and Environmental Health, Norwegian Institute of Public Health, Oslo, Norway., Verner-Carlsson J; Public Health Agency of Sweden, Nobels väg 18, SE-171 82 Solna, Sweden., Ekqvist D; Department of Infectious Diseases, University Hospital Linköping, Sweden., Bråve A; Public Health Agency of Sweden, Nobels väg 18, SE-171 82 Solna, Sweden., Holmes EC; Marie Bashir Institute for Infectious Diseases and Biosecurity, School of Life and Environmental Sciences and School of Medical Sciences, the University of Sydney, Sydney, New South Wales 2006, Australia., Shi W; School of Public Health, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian 271016, China., Pettersson JH; Public Health Agency of Sweden, Nobels väg 18, SE-171 82 Solna, Sweden.; Marie Bashir Institute for Infectious Diseases and Biosecurity, School of Life and Environmental Sciences and School of Medical Sciences, the University of Sydney, Sydney, New South Wales 2006, Australia.; Zoonosis Science Center, Department of Medical Biochemistry and Microbiology, Uppsala University, Sweden.
Jazyk:	angličtina
Zdroj:	One health (Amsterdam, Netherlands) [One Health] 2021 Jan 22; Vol. 12, pp. 100217. Date of Electronic Publication: 2021 Jan 22 (Print Publication: 2021).
DOI:	10.1016/j.onehlt.2021.100217
Abstrakt:	Pathogens associated with haemorrhagic fever commonly have zoonotic origins. The first documented imported case of likely viral severe haemorrhagic fever in Sweden occurred in 1990. Despite extensive study, no aetiological agent was identified. Following retrospective investigation with total RNA-sequencing of samples collected between 7 and 36 days from onset of symptoms we identified dengue virus 3 (DENV-3) and a human pegivirus (HPgV). We conclude that the patient likely suffered from haemorrhagic symptoms due to an atypical severe and undiagnosed dengue infection. Competing Interests: All authors have read the manuscript and have no conflict of interest relating to the manuscript. (© 2021 The Author(s).)
Databáze:	MEDLINE
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