Autophagy Regulation and Photodynamic Therapy: Insights to Improve Outcomes of Cancer Treatment.

Autor:	Martins WK; Laboratory of Cell and Membrane, Anhanguera University of São Paulo, São Paulo, Brazil., Belotto R; Perola Byington Hospital Gynecology - Lasertherapy Clinical Research Department, São Paulo, Brazil., Silva MN; Laboratory of Cell and Membrane, Anhanguera University of São Paulo, São Paulo, Brazil., Grasso D; CONICET, Instituto de Estudios de la Inmunidad Humoral (IDEHU), Universidad de Buenos Aires, Buenos Aires, Argentina., Suriani MD; Institute of Chemistry, Federal University of Uberlândia, Uberlândia, Brazil., Lavor TS; Institute of Chemistry, Federal University of Uberlândia, Uberlândia, Brazil., Itri R; Institute of Physics, University of São Paulo, São Paulo, Brazil., Baptista MS; Institute of Chemistry, University of São Paulo, São Paulo, Brazil., Tsubone TM; Institute of Chemistry, Federal University of Uberlândia, Uberlândia, Brazil.
Jazyk:	angličtina
Zdroj:	Frontiers in oncology [Front Oncol] 2021 Jan 20; Vol. 10, pp. 610472. Date of Electronic Publication: 2021 Jan 20 (Print Publication: 2020).
DOI:	10.3389/fonc.2020.610472
Abstrakt:	Cancer is considered an age-related disease that, over the next 10 years, will become the most prevalent health problem worldwide. Although cancer therapy has remarkably improved in the last few decades, novel treatment concepts are needed to defeat this disease. Photodynamic Therapy (PDT) signalize a pathway to treat and manage several types of cancer. Over the past three decades, new light sources and photosensitizers (PS) have been developed to be applied in PDT. Nevertheless, there is a lack of knowledge to explain the main biochemical routes needed to trigger regulated cell death mechanisms, affecting, considerably, the scope of the PDT. Although autophagy modulation is being raised as an interesting strategy to be used in cancer therapy, the main aspects referring to the autophagy role over cell succumbing PDT-photoinduced damage remain elusive. Several reports emphasize cytoprotective autophagy, as an ultimate attempt of cells to cope with the photo-induced stress and to survive. Moreover, other underlying molecular mechanisms that evoke PDT-resistance of tumor cells were considered. We reviewed the paradigm about the PDT-regulated cell death mechanisms that involve autophagic impairment or boosted activation. To comprise the autophagy-targeted PDT-protocols to treat cancer, it was underlined those that alleviate or intensify PDT-resistance of tumor cells. Thereby, this review provides insights into the mechanisms by which PDT can be used to modulate autophagy and emphasizes how this field represents a promising therapeutic strategy for cancer treatment. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2021 Martins, Belotto, Silva, Grasso, Suriani, Lavor, Itri, Baptista and Tsubone.)
Databáze:	MEDLINE
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