A case of multidrug-resistant Mycobacterium simiae in an elderly woman.

Autor: Lotfi H; Antimicrobial Resistance Research Center Mashhad University of Medical Sciences Mashhad Iran.; Laboratory of Microbiology, Department of Medical Microbiology Ghaem University Hospital, Mashhad University of Medical Sciences Mashhad Iran., Aryan E; Antimicrobial Resistance Research Center Mashhad University of Medical Sciences Mashhad Iran.; Laboratory of Microbiology, Department of Medical Microbiology Ghaem University Hospital, Mashhad University of Medical Sciences Mashhad Iran., Sankian M; Immunobiochemistry Laboratory, Immunology Research Center Mashhad University of Medical Sciences Mashhad Iran., Meshkat Z; Antimicrobial Resistance Research Center Mashhad University of Medical Sciences Mashhad Iran.; Laboratory of Microbiology, Department of Medical Microbiology Ghaem University Hospital, Mashhad University of Medical Sciences Mashhad Iran., Khalifeh Soltani A; Department of Infectious Diseases and Tropical Medicine, Faculty of Medicine Mashhad University of Medical Sciences Mashhad Iran., Alvandi AH; Department of Medical Microbiology Kermanshah University of Medical Sciences Kermanshah Iran., Farsiani H; Antimicrobial Resistance Research Center Mashhad University of Medical Sciences Mashhad Iran.
Jazyk: angličtina
Zdroj: Respirology case reports [Respirol Case Rep] 2021 Feb 01; Vol. 9 (3), pp. e00715. Date of Electronic Publication: 2021 Feb 01 (Print Publication: 2021).
DOI: 10.1002/rcr2.715
Abstrakt: Mycobacterium simiae is an emerging and spreading pathogen in Iran and little data about its drug susceptibility test (DST) and no standard treatment regimen are available. We report a case of multidrug-resistant M . simiae respiratory infection in a 65-year-old woman with a history of previous Mycobacterium tuberculosis infection. The patient was treated with clarithromycin, levofloxacin, and cotrimoxazole for one year and eventually died while still suffering from respiratory problems. For DST, broth microdilution method was used according to the Clinical and Laboratory Standards Institute guidelines as well as molecular DST in clinical isolate. Mycobacterium simiae was resistant to streptomycin, moxifloxacin, clarithromycin, and cotrimoxazole antibiotics and was sensitive to clofazimine and amikacin antibiotics. Inappropriate use of antibiotics without determining the pattern of antibiotic resistance increases the likelihood of resistance and, for resistant specimens, the need to review the treatment protocol and replace antibiotics. Effectiveness based on antibiotic resistance pattern is essential.
(© 2021 The Authors. Respirology Case Reports published by John Wiley & Sons Australia, Ltd on behalf of The Asian Pacific Society of Respirology.)
Databáze: MEDLINE
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