| Autor: |
Agarkov NM; South-Western State University, 94 str. 50 let Oktyabrya, Kursk 305040, Russian Federation, e-mail: vitalaxen@mail.ru.; Belgorod State National Research University, 85 Pobeda str., Belgorod 308015, Russian Federation., Proschayev KI; Academy of Post-Graduate Education of the Federal State Budgetary Institution FMBA of Russia, 30 Volokamskoe shosse, Moscow 123182, Russian Federation., Lutay YA; V.I.Vernadsky Krim Federal University, 4 pr. Akad. Vernadskogo, Simferopol 295007, Republic of Crimea, Russian Federation., Ilnitskiy AN; Academy of Post-Graduate Education of the Federal State Budgetary Institution FMBA of Russia, 30 Volokamskoe shosse, Moscow 123182, Russian Federation., Korneeva SI; Kursk State Medical University, 3 K. Marks str., Kursk 305041, Russian Federation., Markelova AM; Information and Methodological Center for Examination Accounting and Analysis of Medical Devices, 122 str. 50 Let Oktyabrya, Kursk 305040, Russian Federation., Kolomiets VI; Kursk State Medical University, 3 K. Marks str., Kursk 305041, Russian Federation. |
| Abstrakt: |
Traditional treatment regimens for patients with hypertension are not always effective and need to be improved based on the principles of chronobiology. The purpose of this work is to analyze the effect of preventive chronotherapy with amlodipine, lisinopril, and rosuvastatin on daily blood pressure monitoring. In 62 patients with a history of myocardial infarction and hypertension at the age of 60-74, a fixed combination of amlodipine, lisinopril and rosuvastatin at a dose of 5/10/10 mg 2 hours before reaching maximum systolic blood pressure (preventive chronotherapy), in 63 patients with similar diseases and age, this drug is taken at a dose of 5/10/10mg in the evening, and in 58 people - in the morning (traditional treatment). Daily monitoring of blood pressure before and 6 months after treatment was performed by the «SpacelabsMedical» device (USA) with the calculation of generally accepted indicators. The greatest effectiveness of preventive chronotherapy in comparison with other treatment options for achieving the target blood pressure level, reducing the time indices and the variability of systolic blood pressure has been established, which allows us to recommend this fixed combination in geriatric practice. |
