Co-administration of zinc phthalocyanine and quercetin via hybrid nanoparticles for augmented photodynamic therapy.

Autor: Thakur NS; Department of Pharmaceutical Technology (Biotechnology), National Institute of Pharmaceutical Education and Research (NIPER), Sector-67, S.A.S. Nagar-160062, Punjab, India; Department of Nanomaterials and Application Technology, Center of Innovative and Applied Bioprocessing (CIAB), Sector 81 (Knowledge City), Mohali-140306, Punjab, India; School of Pharmaceutical Sciences, University of Geneva, CMU - 1 Rue Michel Servet 1206, Geneva, Switzerland., Mandal N; Department of Pharmaceutical Technology (Biotechnology), National Institute of Pharmaceutical Education and Research (NIPER), Sector-67, S.A.S. Nagar-160062, Punjab, India., Patel G; Department of Pharmaceutical Technology (Biotechnology), National Institute of Pharmaceutical Education and Research (NIPER), Sector-67, S.A.S. Nagar-160062, Punjab, India., Kirar S; Department of Biotechnology, National Institute of Pharmaceutical Education and Research (NIPER), Sector-67, S.A.S. Nagar-160062, Punjab, India., Reddy YN; Department of Nanomaterials and Application Technology, Center of Innovative and Applied Bioprocessing (CIAB), Sector 81 (Knowledge City), Mohali-140306, Punjab, India., Kushwah V; Centre for Pharmaceutical Nanotechnology, Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Sector-67, S.A.S. Nagar-160062, Punjab, India., Jain S; Centre for Pharmaceutical Nanotechnology, Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Sector-67, S.A.S. Nagar-160062, Punjab, India., Kalia YN; School of Pharmaceutical Sciences, University of Geneva, CMU - 1 Rue Michel Servet 1206, Geneva, Switzerland., Bhaumik J; School of Pharmaceutical Sciences, University of Geneva, CMU - 1 Rue Michel Servet 1206, Geneva, Switzerland. Electronic address: jayeeta@ciab.res.in., Banerjee UC; Department of Pharmaceutical Technology (Biotechnology), National Institute of Pharmaceutical Education and Research (NIPER), Sector-67, S.A.S. Nagar-160062, Punjab, India; Department of Biotechnology, National Institute of Pharmaceutical Education and Research (NIPER), Sector-67, S.A.S. Nagar-160062, Punjab, India. Electronic address: ucbanerjee@niper.ac.in.
Jazyk: angličtina
Zdroj: Nanomedicine : nanotechnology, biology, and medicine [Nanomedicine] 2021 Apr; Vol. 33, pp. 102368. Date of Electronic Publication: 2021 Feb 03.
DOI: 10.1016/j.nano.2021.102368
Abstrakt: The photodynamic anticancer activity of a photosensitizer can be further increased by co-administration of a flavonoid. However, this requires that both molecules must be effectively accumulated at the tumor site. Hence, in order to enhance the activity of zinc phthalocyanine (ZnPc, photosensitizer), it was co-encapsulated with quercetin (QC, flavonoid) in lipid polymer hybrid nanoparticles (LPNs) developed using biodegradable & biocompatible materials and prepared using a single-step nanoprecipitation technique. High stability and cellular uptake, sustained release, inherent fluorescence, of ZnPC were observed after encapsulation in the LPNs, which also showed a higher cytotoxic effect in breast carcinoma cells (MCF-7) compared to photodynamic therapy (PDT) alone. In vivo studies in tumor-bearing Sprague Dawley rats demonstrated that the LPNs were able to deliver ZnPc and QC to the tumor site with minimal systemic toxicity and increased antitumor effect. Overall, the photodynamic effect of ZnPc was synergized by QC. This strategy could be highly beneficial for cancer management in the future while nullifying the side effects of chemotherapy.
Competing Interests: Declaration of competing interest All authors declare that he/she has no conflict of interest.
(Copyright © 2021 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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