An explorative approach to understanding individual differences in driving performance and neurocognition in long-term benzodiazepine users.

Autor: Vinckenbosch FRJ; Department of Neuropsychology and Psychopharmacology, Maastricht University, Maastricht, The Netherlands., Vermeeren A; Department of Neuropsychology and Psychopharmacology, Maastricht University, Maastricht, The Netherlands., Vuurman EFPM; Department of Neuropsychology and Psychopharmacology, Maastricht University, Maastricht, The Netherlands., van der Sluiszen NNJJM; Department of Neuropsychology and Psychopharmacology, Maastricht University, Maastricht, The Netherlands., Verster JC; Division Pharmacology, Utrecht University, Utrecht, The Netherlands.; Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands.; Centre for Human Psychopharmacology, Swinburne University, Melbourne, Victoria, Australia., van de Loo AJAE; Division Pharmacology, Utrecht University, Utrecht, The Netherlands.; Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands., van Dijken JH; Department of Clinical and Developmental Neuropsychology, University of Groningen, Groningen, The Netherlands., Veldstra JL; Department of Clinical and Developmental Neuropsychology, University of Groningen, Groningen, The Netherlands., Brookhuis KA; Department of Clinical and Developmental Neuropsychology, University of Groningen, Groningen, The Netherlands., De Waard D; Department of Clinical and Developmental Neuropsychology, University of Groningen, Groningen, The Netherlands., Ramaekers JG; Department of Neuropsychology and Psychopharmacology, Maastricht University, Maastricht, The Netherlands.
Jazyk: angličtina
Zdroj: Human psychopharmacology [Hum Psychopharmacol] 2021 Jul; Vol. 36 (4), pp. e2778. Date of Electronic Publication: 2021 Feb 06.
DOI: 10.1002/hup.2778
Abstrakt: Objective: Previous research reported cognitive and psychomotor impairments in long-term users of benzodiazepine receptor agonists (BZRAs). This article explores the role of acute intoxication and clinical complaints.
Methods: Neurocognitive and on-road driving performance of 19 long-term (≥6 months) regular (≥twice weekly) BZRA users with estimated plasma concentrations, based on self-reported use, exceeding the therapeutic threshold (C BZRA +), and 31 long-term regular BZRA users below (C BZRA -), was compared to that of 76 controls.
Results: BZRA users performed worse on tasks of response speed, processing speed, and sustained attention. Age, but not C BZRA or self-reported clinical complaints, was a significant covariate. Road-tracking performance was explained by C BZRA only. The C BZRA  + group exhibited increased mean standard deviation of lateral position comparable to that at blood-alcohol concentrations of 0.5 g/L.
Conclusions: Functional impairments in long-term BZRA users are not attributable to self-reported clinical complaints or estimated BZRA concentrations, except for road-tracking, which was impaired in CBZRA + users. Limitations to address are the lack of assessment of objective clinical complaints, acute task related stress, and actual BZRA plasma concentrations. In conclusion, the results confirm previous findings that demonstrate inferior performance across several psychomotor and neurocognitive domains in long-term BZRA users.
(© 2021 The Authors. Human Psychopharmacology: Clinical and Experimental published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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