Spatial distribution of Escherichia coli ST131 C subclades in a centralized Canadian urban region.

Autor:	Nobrega D; Department of Population Medicine, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada., Peirano G; Division of Microbiology, Alberta Precision Laboratories, Calgary, Alberta, Canada.; Department of Pathology & Laboratory Medicine, University of Calgary, Cummings School of Medicine, Calgary, Alberta, Canada., Lynch T; Division of Microbiology, Alberta Precision Laboratories, Calgary, Alberta, Canada.; Department of Pathology & Laboratory Medicine, University of Calgary, Cummings School of Medicine, Calgary, Alberta, Canada.; Department of Microbiology, Immunology and Infectious Diseases, University of Calgary, Cummings School of Medicine, Calgary, Alberta, Canada., Finn TJ; Department of Microbiology, Immunology and Infectious Diseases, University of Calgary, Cummings School of Medicine, Calgary, Alberta, Canada., Devinney R; Department of Microbiology, Immunology and Infectious Diseases, University of Calgary, Cummings School of Medicine, Calgary, Alberta, Canada., Pitout JDD; Division of Microbiology, Alberta Precision Laboratories, Calgary, Alberta, Canada.; Department of Pathology & Laboratory Medicine, University of Calgary, Cummings School of Medicine, Calgary, Alberta, Canada.; Department of Microbiology, Immunology and Infectious Diseases, University of Calgary, Cummings School of Medicine, Calgary, Alberta, Canada.; Department of Medical Microbiology, University of Pretoria, Pretoria, South Africa.
Jazyk:	angličtina
Zdroj:	The Journal of antimicrobial chemotherapy [J Antimicrob Chemother] 2021 Apr 13; Vol. 76 (5), pp. 1135-1139.
DOI:	10.1093/jac/dkab020
Abstrakt:	Introduction: Escherichia coli ST131 is the most common multidrug-resistant (MDR) E. coli clone causing bloodstream infections (BSIs) in Calgary. This study describes patient characteristics and spatial distribution of ST131 subclades C1 and C2 causing BSIs in Calgary. Methods: E. coli from blood (n = 685) obtained in Calgary, Canada, (2016) were PCR screened for ST131 and positives (n = 141) underwent whole genome sequencing. Patient characteristics were analysed using Fisher's Exact/t-tests and spatial analysis was used to identify clusters. Results: Overall, 21% of E. coli was identified as ST131 and clade C dominated the population. ST131-C2 was associated with blaCTX-M-15 and significantly more MDR than ST131-C1. The spatial distribution in Calgary showed that ST131-C1 was mainly present in long-term care (LTC) residents whereas ST131-C2 clustered in a specific North East (NE) Calgary sector comprising of six neighbourhoods without LTC centres. This NE sector has high immigration and travel rates from the Indian subcontinent. Conclusions: This study showed that ST131 C subclades have different geographical distribution patterns in Calgary. We believe that recent travel to and immigration from certain high-risk regions for antimicrobial resistance are responsible for the ST131-C2 NE Calgary clustering pattern. (© The Author(s) 2021. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For permissions, please email: journals.permissions@oup.com.)
Databáze:	MEDLINE
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