Toward Studying Cognition in a Dish.

Autor: Rouleau N; Department of Psychology, Algoma University, 1520 Queen Street East, Sault Ste. Marie, Ontario, Canada, P6A 2G4; Department of Biomedical Engineering, Tufts University, Science and Technology Center, 4 Colby Street, Medford, MA 02155, USA., Murugan NJ; Department of Biology, Algoma University, 1520 Queen Street East, Sault Ste. Marie, Ontario, Canada, P6A 2G4., Kaplan DL; Department of Biomedical Engineering, Tufts University, Science and Technology Center, 4 Colby Street, Medford, MA 02155, USA. Electronic address: david.kaplan@tufts.edu.
Jazyk: angličtina
Zdroj: Trends in cognitive sciences [Trends Cogn Sci] 2021 Apr; Vol. 25 (4), pp. 294-304. Date of Electronic Publication: 2021 Feb 02.
DOI: 10.1016/j.tics.2021.01.005
Abstrakt: Bioengineered neural tissues help advance our understanding of neurodevelopment, regeneration, and neural disease; however, it remains unclear whether they can replicate higher-order functions including cognition. Building upon technical achievements in the fields of biomaterials, tissue engineering, and cell biology, investigators have generated an assortment of artificial brain structures and cocultured circuits. Though they have displayed basic electrochemical signaling, their capacities to generate minimal patterns of information processing suggestive of high-order cognitive analogues have not yet been explored. Here, we review the current state of neural tissue engineering and consider the possibility of a study of cognition in vitro. We adopt a practical definition of minimal cognition, anticipate problems of measurement, and discuss solutions toward a study of cognition in a dish.
Competing Interests: Declaration of Interests No interests are declared.
(Copyright © 2021 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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