Assessment of Subclinical Renal Glomerular and Tubular Dysfunction in Children with Beta Thalassemia Major.

Autor:	Mahmoud AA; Department of Pediatrics, Faculty of Medicine, Menoufia University, Shebin Elkom 32511, Egypt., Elian DM; Department of Pediatrics, Faculty of Medicine, Menoufia University, Shebin Elkom 32511, Egypt.; Department of Pediatrics, College of Medicine, King Faisal University, Al-Ahsa 31982, Saudi Arabia., Abd El Hady NM; Department of Pediatrics, Faculty of Medicine, Menoufia University, Shebin Elkom 32511, Egypt., Abdallah HM; Department of Clinical Pathology, National Liver Institute, Menoufia University, Shebin Elkom 32511, Egypt., Abdelsattar S; Department of Clinical Biochemistry and Molecular Diagnostics, National Liver Institute, Menoufia University, Shebin Elkom 32511, Egypt., Khalil FO; Department of Clinical and Molecular Microbiology and Immunology, National Liver Institute, Menoufia University, Shebin Elkom 32511, Egypt., Abd El Naby SA; Department of Pediatrics, Faculty of Medicine, Menoufia University, Shebin Elkom 32511, Egypt.
Jazyk:	angličtina
Zdroj:	Children (Basel, Switzerland) [Children (Basel)] 2021 Feb 03; Vol. 8 (2). Date of Electronic Publication: 2021 Feb 03.
DOI:	10.3390/children8020100
Abstrakt:	Background: A good survival rate among patients with beta thalassemia major (beta-TM) has led to the appearance of an unrecognized renal disease. Therefore, we aimed to assess the role of serum cystatin-C as a promising marker for the detection of renal glomerular dysfunction and N-acetyl beta-D-glucosaminidase (NAG) and kidney injury molecule 1 (KIM-1) as potential markers for the detection of renal tubular injury in beta-TM children. Methods: This case-control study was implemented on 100 beta-TM children receiving regular blood transfusions and undergoing iron chelation therapy and 100 healthy children as a control group. Detailed histories of complete physical and clinical examinations were recorded. All subjected children underwent blood and urinary investigations. Results: There was a significant increase in serum cystatin-C ( p < 0.001) and a significant decrease in eGFR in patients with beta-TM compared with controls ( p = 0.01). There was a significant increase in urinary NAG, KIM-1, UNAG/Cr, and UKIM-1/Cr ( p < 0.001) among thalassemic children, with a significant positive correlation between serum cystatin-C, NAG and KIM-1 as regards serum ferritin, creatinine, and urea among thalassemic patients. A negative correlation between serum cystatin-C and urinary markers with eGFR was noted. Conclusion: Serum cystatin-C is a good marker for detection of glomerular dysfunction. NAG and KIM-1 may have a predictive role in the detection of kidney injury in beta-TM children.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu