New insights into regulatory B cells biology in viral, bacterial, and parasitic infections.

Autor: Sanaei MJ; Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran., Nahid-Samiei M; Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran., Abadi MSS; Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran; Cancer Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran., Arjmand MH; Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran; Cancer Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran., Ferns GA; Brighton & Sussex Medical School, Division of Medical Education, Falmer, Brighton, Sussex BN1 9PH, UK., Bashash D; Department of Hematology and Blood Banking, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Rahimian G; Department of Internal Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran., Bagheri N; Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran. Electronic address: n.bagheri1985@gmail.com.
Jazyk: angličtina
Zdroj: Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases [Infect Genet Evol] 2021 Apr; Vol. 89, pp. 104753. Date of Electronic Publication: 2021 Feb 02.
DOI: 10.1016/j.meegid.2021.104753
Abstrakt: B lymphocytes are primarily well known for their contribution to immunity by antibody production, antigen presentation and, the production of cytokines. In recent years several studies demonstrated the existence of B cells with regulatory functions, which have been termed regulatory B cells (B regs ), similar to regulatory T cells (T regs ). B regs are a subpopulation of B cells that have immunosuppressive effects via the production of regulatory cytokines including interleukin-10 (IL-10), transforming growth factor-β (TGF-β), and IL-35. B regs limit host defense against various pathogens. In addition, B regs contribute to increased levels of regulatory cytokines and leads to an induction of suppressive T regs , which exert broader suppressive functions against various pathogens. The high percentage of B regs is positively associated with viral and bacterial load and can contribute to poor vaccine responses. B regs can also facilitate pathogen survival at an early stage of infection, and subsequently cause increased severity of disease by inhibiting pro-inflammatory cytokine production, macrophage activation, and inflammatory T cells activation such as Th1, Th17, and Th22. Also, B regs afford protection against the hyper-inflammatory response in parasitic infections. Here we review the central role of B regs in many major bacterial and viral human infections, and provide an overview of the immunoregulatory mechanisms used by B regs .
(Copyright © 2021 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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