| Autor: |
Hrubeniuk TJ; Cardiometabolic Exercise and Lifestyle Laboratory, University of New Brunswick, Fredericton, New Brunswick, Canada.; Interdisciplinary Studies, School of Graduate Studies, University of New Brunswick, Fredericton, New Brunswick, Canada., Hay JL; Children Hospital Research Institute of Manitoba, Winnipeg, Manitoba, Canada.; Faculty of Kinesiology and Recreation Management, University of Manitoba, Winnipeg, Manitoba, Canada., MacIntosh AC; Children Hospital Research Institute of Manitoba, Winnipeg, Manitoba, Canada., Wicklow B; Children Hospital Research Institute of Manitoba, Winnipeg, Manitoba, Canada.; Department of Pediatrics and Child Health, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada., Wittmeier K; Children Hospital Research Institute of Manitoba, Winnipeg, Manitoba, Canada.; Department of Pediatrics and Child Health, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada., McGavock JM; Children Hospital Research Institute of Manitoba, Winnipeg, Manitoba, Canada.; Department of Pediatrics and Child Health, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada., Sénéchal M; Cardiometabolic Exercise and Lifestyle Laboratory, University of New Brunswick, Fredericton, New Brunswick, Canada.; Faculty of Kinesiology, University of New Brunswick, Fredericton, New Brunswick, Canada. |
| Abstrakt: |
This study determined the interindividual variation in the cardiometabolic response to 6 months of moderate or vigorous intensity exercise training (ET) among youth at risk for type 2 diabetes mellitus. Youth were randomized to moderate intensity ET (45-55% heart rate reserve; n = 31), vigorous intensity ET (70-85% heart rate reserve; n = 37), or control ( n = 36). Only those attending ≥70% of ET sessions were included. Cardiometabolic measures included insulin sensitivity, hepatic triglyceride content, visceral adipose area, and cardiorespiratory fitness. The contribution of ET to interindividual variation was determined using the standard deviation of individual responses (SD IR ) and considered meaningful if the SD IR surpassed the smallest worthwhile difference (SWD), calculated as 0.2 × the standard deviation of the control group baseline values. ET meaningfully contributed to the interindividual variation among changes in peak oxygen uptake following moderate (SD IR : 2.04) and vigorous (SD IR : 3.43) ET (SWD: 1.17 mL·kg fat free mass -1 ·min -1 ), body fat percentage and hepatic triglyceride content following moderate-intensity ET (SD IR : 1.64, SWD: 1.05%; SD IR : 10.08, SWD: 1.06%, respectively), and visceral fat mass following vigorous ET (SD IR : 11.06, SWD: 7.13 cm 2 ). Variation in the changes in insulin sensitivity were not influenced by ET. The contribution of ET to interindividual variation appears to be influenced by the desired outcome and prescribed intensity. Trial registration at ClinicalTrials.gov (identifier no.: NCT00755547). Novelty: The contribution of exercise to interindividual variation following training depends on the outcome and exercise intensity. Increasing exercise intensity does not systematically reduce non-response among youth at risk for type 2 diabetes. |
