Geroprotective potential of genetic and pharmacological interventions to endogenous hydrogen sulfide synthesis in Drosophila melanogaster.

Autor: Shaposhnikov MV; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991, Moscow, Russian Federation.; Institute of Biology of Komi Science Center, Ural Branch of RAS, 167982, Syktyvkar, Russian Federation., Zemskaya NV; Institute of Biology of Komi Science Center, Ural Branch of RAS, 167982, Syktyvkar, Russian Federation., Koval LA; Institute of Biology of Komi Science Center, Ural Branch of RAS, 167982, Syktyvkar, Russian Federation., Schegoleva EV; Institute of Biology of Komi Science Center, Ural Branch of RAS, 167982, Syktyvkar, Russian Federation., Yakovleva DV; Institute of Biology of Komi Science Center, Ural Branch of RAS, 167982, Syktyvkar, Russian Federation., Ulyasheva NS; Institute of Biology of Komi Science Center, Ural Branch of RAS, 167982, Syktyvkar, Russian Federation., Gorbunova AA; Institute of Biology of Komi Science Center, Ural Branch of RAS, 167982, Syktyvkar, Russian Federation., Minnikhanova NR; Institute of Biology of Komi Science Center, Ural Branch of RAS, 167982, Syktyvkar, Russian Federation., Moskalev AA; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991, Moscow, Russian Federation. amoskalev@ib.komisc.ru.; Institute of Biology of Komi Science Center, Ural Branch of RAS, 167982, Syktyvkar, Russian Federation. amoskalev@ib.komisc.ru.
Jazyk: angličtina
Zdroj: Biogerontology [Biogerontology] 2021 Apr; Vol. 22 (2), pp. 197-214. Date of Electronic Publication: 2021 Feb 05.
DOI: 10.1007/s10522-021-09911-4
Abstrakt: Endogenous hydrogen sulfide (H 2 S) is a gasotransmitter with a wide range of physiological functions. Aging is accompanied by disruption of H 2 S homeostasis, therefore, interventions to the processes of H 2 S metabolism to maintain its balance may have geroprotective potential. Here we demonstrated the additive geroprotective effect of combined genetic and pharmacological interventions to the hydrogen sulfide biosynthesis system by overexpression of cystathionine-β-synthase and cystathionine-γ-lyase genes and treatment with precursors of H 2 S synthesis cysteine (Cys) and N-acetyl-L-cysteine (NAC). The obtained results suggest that additive effects of genetic and pharmacological interventions to H 2 S metabolism may be associated with the complex interaction between beneficial action of H 2 S production and prevention of adverse effects of excess H 2 S production by Cys and NAC treatment.
Databáze: MEDLINE
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