Role of ABCB1 in mediating chemoresistance of triple-negative breast cancers.

Autor:	Abd El-Aziz YS; Northern Clinical School, Faculty of Medicine and Health, University of Sydney, NSW, Australia.; Kolling Institute of Medical Research, St Leonards, NSW, Australia.; Oral Pathology Department, Faculty of Dentistry, Tanta University, Tanta, Egypt., Spillane AJ; Melanoma Institute Australia, University of Sydney, Wollstonecraft, NSW, Australia.; Northern Sydney Cancer Centre, Royal North Shore Hospital, St Leonards, NSW, Australia., Jansson PJ; Northern Clinical School, Faculty of Medicine and Health, University of Sydney, NSW, Australia.; Kolling Institute of Medical Research, St Leonards, NSW, Australia.; Cancer Drug Resistance Program, University of Sydney, Sydney, New South Wales 2006, Australia., Sahni S; Northern Clinical School, Faculty of Medicine and Health, University of Sydney, NSW, Australia.; Kolling Institute of Medical Research, St Leonards, NSW, Australia.
Jazyk:	angličtina
Zdroj:	Bioscience reports [Biosci Rep] 2021 Feb 26; Vol. 41 (2).
DOI:	10.1042/BSR20204092
Abstrakt:	Triple-negative breast cancer (TNBC) is a group of breast cancers which neither express hormonal receptors nor human epidermal growth factor receptor. Hence, there is a lack of currently known targeted therapies and the only available line of systemic treatment option is chemotherapy or more recently immune therapy. However, in patients with relapsed disease after adjuvant or neoadjuvant therapy, resistance to chemotherapeutic agents has often developed, which results in poor treatment response. Multidrug resistance (MDR) has emerged as an important mechanism by which TNBCs mediate drug resistance and occurs primarily due to overexpression of ATP-binding cassette (ABC) transporter proteins such as P-glycoprotein (Pgp). Pgp overexpression had been linked to poor outcome, reduced survival rates and chemoresistance in patients. The aim of this mini-review is to provide a topical overview of the recent studies and to generate further interest in this critical research area, with the aim to develop an effective and safe approach for overcoming Pgp-mediated chemoresistance in TNBC. (© 2021 The Author(s).)
Databáze:	MEDLINE
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