Immediate and after effects of transcranial direct-current stimulation in the mouse primary somatosensory cortex.

Autor: Sánchez-León CA; Department of Physiology, Anatomy and Cell Biology, Pablo de Olavide University, Ctra. de Utrera, km. 1, 41013, Seville, Spain., Cordones I; Department of Physiology, Anatomy and Cell Biology, Pablo de Olavide University, Ctra. de Utrera, km. 1, 41013, Seville, Spain., Ammann C; HM CINAC, Hospital Universitario HM Puerta del Sur, HM Hospitales, Madrid, Spain., Ausín JM; Instituto de Investigación E Innovación en Bioingeniería, Universidad Politécnica de Valencia, Valencia, Spain., Gómez-Climent MA; Department of Physiology, Anatomy and Cell Biology, Pablo de Olavide University, Ctra. de Utrera, km. 1, 41013, Seville, Spain., Carretero-Guillén A; Department of Physiology, Anatomy and Cell Biology, Pablo de Olavide University, Ctra. de Utrera, km. 1, 41013, Seville, Spain., Sánchez-Garrido Campos G; Department of Physiology, Anatomy and Cell Biology, Pablo de Olavide University, Ctra. de Utrera, km. 1, 41013, Seville, Spain., Gruart A; Department of Physiology, Anatomy and Cell Biology, Pablo de Olavide University, Ctra. de Utrera, km. 1, 41013, Seville, Spain., Delgado-García JM; Department of Physiology, Anatomy and Cell Biology, Pablo de Olavide University, Ctra. de Utrera, km. 1, 41013, Seville, Spain., Cheron G; Laboratory of Electrophysiology, Université de Mons, Mons, Belgium.; Laboratory of Neurophysiology and Movement Biomechanics, ULB Neuroscience Institute, Université Libre de Bruxelles, Brussels, Belgium., Medina JF; Department of Neuroscience, Baylor College of Medicine, Houston, TX, USA., Márquez-Ruiz J; Department of Physiology, Anatomy and Cell Biology, Pablo de Olavide University, Ctra. de Utrera, km. 1, 41013, Seville, Spain. jmarquez@upo.es.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2021 Feb 04; Vol. 11 (1), pp. 3123. Date of Electronic Publication: 2021 Feb 04.
DOI: 10.1038/s41598-021-82364-4
Abstrakt: Transcranial direct-current stimulation (tDCS) is a non-invasive brain stimulation technique consisting in the application of weak electric currents on the scalp. Although previous studies have demonstrated the clinical value of tDCS for modulating sensory, motor, and cognitive functions, there are still huge gaps in the knowledge of the underlying physiological mechanisms. To define the immediate impact as well as the after effects of tDCS on sensory processing, we first performed electrophysiological recordings in primary somatosensory cortex (S1) of alert mice during and after administration of S1-tDCS, and followed up with immunohistochemical analysis of the stimulated brain regions. During the application of cathodal and anodal transcranial currents we observed polarity-specific bidirectional changes in the N1 component of the sensory-evoked potentials (SEPs) and associated gamma oscillations. On the other hand, 20 min of cathodal stimulation produced significant after-effects including a decreased SEP amplitude for up to 30 min, a power reduction in the 20-80 Hz range and a decrease in gamma event related synchronization (ERS). In contrast, no significant changes in SEP amplitude or power analysis were observed after anodal stimulation except for a significant increase in gamma ERS after tDCS cessation. The polarity-specific differences of these after effects were corroborated by immunohistochemical analysis, which revealed an unbalance of GAD 65-67 immunoreactivity between the stimulated versus non-stimulated S1 region only after cathodal tDCS. These results highlight the differences between immediate and after effects of tDCS, as well as the asymmetric after effects induced by anodal and cathodal stimulation.
Databáze: MEDLINE
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