Evaluation of bronchial challenge test results for use in assessment of paediatric eczema: a retrospective series.

Autor:	Hon KL; Department of Paediatrics, The Chinese University of Hong Kong, Hong Kong., Ng AHY; Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong., Chan CCC; Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong., Ho PXY; Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong., Tsoi EPM; Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong., Tsang KYC; Department of Paediatrics, The Chinese University of Hong Kong, Hong Kong., Ko FW; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong., Leung TF; Department of Paediatrics, The Chinese University of Hong Kong, Hong Kong.
Jazyk:	angličtina
Zdroj:	Hong Kong medical journal = Xianggang yi xue za zhi [Hong Kong Med J] 2021 Feb; Vol. 27 (1), pp. 27-34. Date of Electronic Publication: 2021 Feb 04.
DOI:	10.12809/hkmj208453
Abstrakt:	Background: Atopic dermatitis (AD), asthma, and allergic rhinitis are associated diseases involved in the atopic march. The bronchial challenge test (BCT) is a tool that evaluates airway hyperresponsiveness in patients with asthma. This study aimed to evaluate whether a positive BCT result is useful in assessment of paediatric AD. Methods: This retrospective case series included 284 patients with AD who had BCT results. Clinical information and laboratory parameters were reviewed, including AD severity (using the SCORing Atopic Dermatitis [SCORAD]), skin hydration, and transepidermal water loss. Results: Of the 284 patients who had BCT, 106 had positive BCT results and 178 had negative BCT results. A positive BCT result was associated with a history of asthma (P<0.0005), sibling with asthma (P=0.048), serum immunoglobulin E (P=0.045), eosinophil count (P=0.017), and sensitisation to food allergens in the skin prick test (P=0.027). There was no association between a positive BCT result and personal allergic rhinitis, parental atopy, sibling allergic rhinitis or AD, skin prick response to dust mites, objective SCORAD score, skin hydration, transepidermal water loss, exposure to smoking, incense burning, cat or dog ownership, or AD treatment aspects (eg, food avoidance and traditional Chinese medicine). Logistic regression showed significant associations of a positive BCT result with a history of asthma (adjusted odds ratio=4.05; 95% confidence interval=1.92-8.55; P<0.0005) and sibling atopy (adjusted odds ratio=2.25; 95% confidence interval=1.03-4.92; P=0.042). Conclusions: In patients with paediatric AD, a positive BCT result was independently and positively associated with personal history of asthma and sibling history of atopy, but not with any other clinical parameters. Competing Interests: As the editor of the journal, KL Hon was not involved in the peer review process. Other authors have disclosed no conflicts of interest.
Databáze:	MEDLINE
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