Accidentally discovered high INR in pregnancy unmasks an inherited factor VII (FVII) deficiency that is paradoxically associated with thrombotic tendency.
| Autor: | Elkhateb IT; Obstetrics and Gynecology Department, Newgiza University, Giza, Giza, Egypt., Mousa A; Obstetrics and Gynecology Department, Cairo University Kasr Alainy Faculty of Medicine, Cairo, Egypt dr_abdallamousa@yahoo.com., Mohye Eldeen R; Dermatology Department, Cairo University Kasr Alainy Faculty of Medicine, Cairo, Egypt., Soliman Y; Dermatology Department, Albert Einstein College of Medicine, Bronx, New York, USA. |
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| Jazyk: | angličtina |
| Zdroj: | BMJ case reports [BMJ Case Rep] 2021 Feb 04; Vol. 14 (2). Date of Electronic Publication: 2021 Feb 04. |
| DOI: | 10.1136/bcr-2020-237781 |
| Abstrakt: | A 32-year-old multiparous obese woman was referred to our center at 37 weeks of twin gestation. She was referred for birth planning following an accidentally discovered high international normalised ratio (INR) in routine preoperative labs. Her history was significant for recurrent pregnancy-associated deep venous thrombosis as well as two early pregnancy losses. Further work-up revealed transaminitis, mild splenomegaly and high lupus anticoagulant titre. A multidisciplinary team of physicians from the high-risk pregnancy, anaesthesiology, haematology, gastroenterology and hepatology departments put a management plan; it culminated into uncomplicated delivery of the patient by repeated caesarian section. The team was also able to figure out the cause of the patient's high INR that is associated with thrombophilia rather than haemophilia. Competing Interests: Competing interests: None declared. (© BMJ Publishing Group Limited 2021. No commercial re-use. See rights and permissions. Published by BMJ.) |
| Databáze: | MEDLINE |
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