Lipid nanoparticles with improved biopharmaceutical attributes for tuberculosis treatment.

Autor: Gordillo-Galeano A; Universidad Nacional de Colombia, Sede Bogotá. Facultad de Ciencias, Departamento de Farmacia, Ciudad Universitaria, Carrera 30 45-03, Edificio 450, Bogotá 111321, Colombia., Ospina-Giraldo LF; Universidad Nacional de Colombia, Sede Bogotá. Facultad de Ciencias, Departamento de Farmacia, Ciudad Universitaria, Carrera 30 45-03, Edificio 450, Bogotá 111321, Colombia., Mora-Huertas CE; Universidad Nacional de Colombia, Sede Bogotá. Facultad de Ciencias, Departamento de Farmacia, Ciudad Universitaria, Carrera 30 45-03, Edificio 450, Bogotá 111321, Colombia. Electronic address: cemorah@unal.edu.co.
Jazyk: angličtina
Zdroj: International journal of pharmaceutics [Int J Pharm] 2021 Mar 01; Vol. 596, pp. 120321. Date of Electronic Publication: 2021 Feb 02.
DOI: 10.1016/j.ijpharm.2021.120321
Abstrakt: Tuberculosis is a topic of relevance worldwide because of the social and biological factors that triggered the disease and the economic burden on the health-care systems that imply its therapeutic treatment. Challenges to handle these issues include, among others, research on technological breakthroughs modifying the drug regimens to facilitate therapy adherence, avoid mycobacterium drug resistance, and minimize toxic side-effects. Lipid nanoparticles arise as a promising strategy in this respect as deduced from the reported scientific data. They are prepared from biodegradable and biocompatible starting materials and compared to the use of the free drugs, the entrapment of active molecules into the carriers might lead to both dose reduction and controlled delivery. Moreover, the target to the lung, the organ mainly affected by the disease, could be possible if the particle surface is modified. Although conclusive statements cannot be made considering the limited number of available research works, looking into what has been achieved up to now definitively encourages to continue investigations in this regard.
(Copyright © 2021 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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