Priapism in sickle cell disease: Associations between NOS3 and EDN1 genetic polymorphisms and laboratory biomarkers.

Autor: Figueiredo CVB; Instituto Gonçalo Moniz/Fundação Oswaldo Cruz, Salvador, Bahia, Brasil.; Universidade Federal da Bahia, Salvador, Bahia, Brasil., Santiago RP; Instituto Gonçalo Moniz/Fundação Oswaldo Cruz, Salvador, Bahia, Brasil.; Universidade Federal da Bahia, Salvador, Bahia, Brasil., da Guarda CC; Instituto Gonçalo Moniz/Fundação Oswaldo Cruz, Salvador, Bahia, Brasil.; Universidade Federal da Bahia, Salvador, Bahia, Brasil., Oliveira RM; Instituto Gonçalo Moniz/Fundação Oswaldo Cruz, Salvador, Bahia, Brasil.; Universidade Federal da Bahia, Salvador, Bahia, Brasil., Fiuza LM; Instituto Gonçalo Moniz/Fundação Oswaldo Cruz, Salvador, Bahia, Brasil.; Universidade Federal da Bahia, Salvador, Bahia, Brasil., Yahouédéhou SCMA; Instituto Gonçalo Moniz/Fundação Oswaldo Cruz, Salvador, Bahia, Brasil.; Universidade Federal da Bahia, Salvador, Bahia, Brasil., Carvalho SP; Instituto Gonçalo Moniz/Fundação Oswaldo Cruz, Salvador, Bahia, Brasil.; Universidade Federal da Bahia, Salvador, Bahia, Brasil., Neres JSDS; Instituto Gonçalo Moniz/Fundação Oswaldo Cruz, Salvador, Bahia, Brasil.; Universidade Federal da Bahia, Salvador, Bahia, Brasil., Oliveira AMJ; Instituto Gonçalo Moniz/Fundação Oswaldo Cruz, Salvador, Bahia, Brasil.; Universidade Federal da Bahia, Salvador, Bahia, Brasil., Fonseca CA; Universidade Federal da Bahia, Salvador, Bahia, Brasil., Nascimento VML; Fundação de Hematologia e Hemoterapia da Bahia (HEMOBA), Salvador, Bahia, Brasil., Lyra IM; Complexo Hospitalar Universitário Professor Edgard Santos, Salvador, Bahia, Brasil., Aleluia MM; Universidade Estadual de Santa Cruz, Ilhéus, Bahia, Brasil., Goncalves MS; Instituto Gonçalo Moniz/Fundação Oswaldo Cruz, Salvador, Bahia, Brasil.; Universidade Federal da Bahia, Salvador, Bahia, Brasil.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2021 Feb 04; Vol. 16 (2), pp. e0246067. Date of Electronic Publication: 2021 Feb 04 (Print Publication: 2021).
DOI: 10.1371/journal.pone.0246067
Abstrakt: Priapism is a urologic emergency characterized by an uncontrolled, persistent and painful erection in the absence of sexual stimulation, which can lead to penile fibrosis and impotence. It is highly frequent in sickle cell disease (SCD) associated with hemolytic episodes. Our aim was to investigate molecules that may participate in the regulation of vascular tone. Eighty eight individuals with SCD were included, of whom thirty-seven reported a history of priapism. Priapism was found to be associated with alterations in laboratory biomarkers, as well as lower levels of HbF. Patients with sickle cell anemia using hydroxyurea and those who received blood products seemed to be less affected by priapism. Multivariate analysis suggested that low HbF and NOm were independently associated with priapism. The frequency of polymorphisms in genes NOS3 and EDN1 was not statistically significant between the studied groups, and the presence of the variant allele was not associated with alterations in NOm and ET-1 levels in patients with SCD. The presence of the variant allele in the polymorphisms investigated did not reveal any influence on the occurrence priapism. Future studies involving larger samples, as well as investigations including patients in priapism crisis, could contribute to an enhanced understanding of the development of priapism in SCD.
Competing Interests: The authors deny the existence of any conflicts of interest with regard to the publication of our results.
Databáze: MEDLINE
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