Low use of condom and high STI incidence among men who have sex with men in PrEP programs.

Autor: Ayerdi Aguirrebengoa O; Centro Sanitario Sandoval, Hospital Clínico San Carlos, IdISSC, Madrid, Spain.; Universidad Complutense de Madrid, Madrid, Spain., Vera García M; Centro Sanitario Sandoval, Hospital Clínico San Carlos, IdISSC, Madrid, Spain., Arias Ramírez D; Medicina Interna, Hospital Clínico San Carlos, IdISSC, Madrid, Spain., Gil García N; Medicina Interna, Hospital Clínico San Carlos, IdISSC, Madrid, Spain., Puerta López T; Centro Sanitario Sandoval, Hospital Clínico San Carlos, IdISSC, Madrid, Spain., Clavo Escribano P; Centro Sanitario Sandoval, Hospital Clínico San Carlos, IdISSC, Madrid, Spain., Ballesteros Martín J; Centro Sanitario Sandoval, Hospital Clínico San Carlos, IdISSC, Madrid, Spain., Lejarraga Cañas C; Centro Sanitario Sandoval, Hospital Clínico San Carlos, IdISSC, Madrid, Spain., Fernandez Piñeiro N; Centro Sanitario Sandoval, Hospital Clínico San Carlos, IdISSC, Madrid, Spain., Fuentes Ferrer ME; Servicio de Medicina Preventiva, IdISSC, Universidad Alfonso X el Sabio, Madrid, Spain., García Lotero M; Centro Sanitario Sandoval, Hospital Clínico San Carlos, IdISSC, Madrid, Spain., Hurtado Gallegos E; Centro Sanitario Sandoval, Hospital Clínico San Carlos, IdISSC, Madrid, Spain., Raposo Utrilla M; Centro Sanitario Sandoval, Hospital Clínico San Carlos, IdISSC, Madrid, Spain., Estrada Pérez V; Universidad Complutense de Madrid, Madrid, Spain.; Hospital Fundación Jiménez Díaz, Madrid, Spain., Del Romero Guerrero J; Centro Sanitario Sandoval, Hospital Clínico San Carlos, IdISSC, Madrid, Spain., Rodríguez Martín C; Centro Sanitario Sandoval, Hospital Clínico San Carlos, IdISSC, Madrid, Spain.; Universidad Complutense de Madrid, Madrid, Spain.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2021 Feb 04; Vol. 16 (2), pp. e0245925. Date of Electronic Publication: 2021 Feb 04 (Print Publication: 2021).
DOI: 10.1371/journal.pone.0245925
Abstrakt: Objective: Since the recent introduction of preexposure prophylaxis (PrEP), several studies have reported a decrease in the use of condoms and a rise in STIs among users. This rise in risk behavior associated with the advent of PrEP is known as "risk compensation." The aim of this study is to measure clinical and behavioral changes associated with the introduction of PrEP by analyzing condom use for anal intercourse, number of sexual partners, sexualized drug use and STI incidence.
Methods: We performed a retrospective descriptive study of PrEP users followed every 3months over a 2-year period spanning 2017-2019 in a referral clinic specializing in STI/HIV in Madrid, Spain. One hundred ten men who have sex with men and transgender women underwent regular screening for STIs and hepatitis C virus (HCV) infection. Sociodemographic, clinical, and behavioral data were gathered for all subjects studied.
Results: The risk compensation observed in this study consisted primarily of a lower rate of condom use, while the number of sexual partners and recreational drug consumption remained stable. We observed a very high incidence of STIs in this sample, particularly rectal gonorrhea and chlamydia. The factors shown to be independently associated with the presence of an STI on multivariate analysis were age below 30 years and over 10 sexual partners/month.
Conclusion: The incidence of STI acquisition was higher than expected, indicating a need for strategies to minimize this impact, particularly among younger individuals with a higher number of sexual partners.
Competing Interests: The authors have declared that no competing interests exist.
Databáze: MEDLINE
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